Author: Monyo in cowhide sauce

Talk a few words

Hello ducks, I am a cowhide sauce that loves life. I am keen to share the pits I stepped on and the weeds I pulled out. I hope my sharing can help the treasures, and I will not get lost!

The Dragon Boat Festival is coming soon. Has everyone eaten zongzi? All my friends who are familiar with me know that I am a real foodie, and I started to eat zongzi before the festival. No, I bought a lot of rice dumplings with novel tastes with the idea of early adopters. Before the Dragon Boat Festival, let’s share the taste and taste of these novel zongzi, and which one is the best.

1 Sanquan Jasmine Longjing Zongzi/Rose Black Tea Zongzi

This is a new Chinese zongzi produced by Sanquan, which has two flavors: jasmine Longjing tea and rose black tea. I bought both models. Let’s try them in turn. The weight of a single package is 200g, and each package contains 4 zongzi, which is equivalent to each zongzi with 50g of zongzi leaves. It belongs to a very mini small zongzi.

Jasmine Longjing zongzi is selected from Hangzhou Longjing and Yunnan Jasmine as the main raw materials. When the leaves of zongzi are opened, you can see that the zongzi has the faint natural green color of Longjing tea, rather than the green and transparent sense of science and technology on the packaging. Jasmine petals can also be seen in glutinous rice, and the stuffing inside is jasmine stuffing, which smells full of flower fragrance and tea fragrance. In one bite, jasmine fragrance, Longjing tea fragrance and zongzi leaf fragrance are mixed together, and the taste is very fresh and the sweetness is just right. It tastes like a dessert without the greasy feeling of traditional zongzi at all.

The raw materials of rose black tea dumplings are black tea and Yunnan roses. When you open the leaves, you can see that the appearance of dumplings is also natural light red and black, and it smells full of tea and roses. Some rose petals can be seen in the rose stuffing inside. The fragrance of roses, zongye and black tea is integrated into one, like a delicate Soviet-style sweet spot, but it is not too sweet, but just right.

2 Wufangzhai Zi Nuo Li Rong Zongzi

Wufangzhai is the representative brand of Jiaxing Zongzi. I believe many friends have eaten his egg yolk pork dumplings, ribs dumplings, big meat dumplings and so on. Not long ago, I just brushed this purple glutinous chestnut dumpling. I haven’t eaten it before. I took advantage of the festive atmosphere this year to taste it. This zongzi belongs to the standard zongzi size, with a single zongzi of 100g.

Zongzi is mainly composed of glutinous rice and purple glutinous rice. It seems that there is a little more glutinous rice, about 1/3 purple glutinous rice and 2/3 glutinous rice. This zongzi looks unremarkable, but it tastes delicious and chewy, and you can taste the mellow zongzi fragrance with one bite.

The addition of chestnut stuffing is also relatively large. This stuffing is very good, just right in sweetness, and it tastes very delicate. It can’t be stopped after eating. It is highly recommended.

3 Miss Black Sesame Walnut Five Black Grains Zongzi

Missing is a brand that started as a black sesame seed. It also introduced five black zongzi with black sesame seeds and walnuts. This zongzi has a pack of 400g, there are five in total, and the weight of a single zongzi is 80g. But from the appearance, it looks similar to the size of the previous tea brown. It should be that this zongzi has more materials and is thicker.

This zongzi looks completely purple. Besides glutinous rice, there are black rice, black kidney beans, black wheat, black quinoa and walnut kernels. It smells like grains mixed with zongzi leaves and tastes chewy.

The black sesame filling in the middle is the taste of his black sesame paste, which is very sweet but not too sweet. With the taste of miscellaneous grains, it goes straight to the taste buds on the tip of the tongue and can’t stop eating it if you are slapped.

40,000 Shouzhai Panda Bangbangzong

This kind of zongzi is different from ordinary zongzi wrapped in leaves. It is wrapped in a bamboo tube, with beautiful outer packaging and the shape of a national treasure, which is very eye-catching.

Each zongzi occupies a bamboo tube, and the weight given is relatively sufficient. A single zongzi is 180g, which belongs to the big zongzi. A packet of zongzi has four flavors, namely, milk yellow preserved fruit flavor, blood glutinous rice and taro paste flavor, eight-treasure bean paste flavor and yellow rice and jujube flavor.

Zongzi can be put into a bamboo tube and sealed with zongzi leaves, which should make the taste of zongzi more layered, with bamboo fragrance on one side and zongzi leaves on the other.

I presented four long chopsticks and a bamboo stick. I want to poke them out when I eat them. This design is quite interesting.

Of the four flavors, the rice dumplings with the taste of bloody glutinous rice and taro mud are the best. The taro mud is chewy and delicious with the fresh bamboo fragrance. It is simply not too delicious. It is highly recommended. The taste of Babao bean paste is similar to that of traditional zongzi. There is not much added Babao rice, which has little effect on the taste. What can be felt on the tip of the tongue is more the natural fragrance of zongzi and bamboo.

The taste and taste of rice dumplings with milk yellow preserved fruit are not bad. The preserved fruit is filled with a lot of stuffing, which tastes sweet and soft. Sweetheart lovers should like this taste. The rice dumplings with the flavor of yellow rice and candied dates are very similar to the traditional candied dates in taste and taste, but such a big rice dumpling with only one candied date is a bit not full of flavor, and it tastes more like the taste of alkaline rice dumplings, which I personally feel is average.

5 wonderful durian ice dumplings/mango ice dumplings

This kind of ice-covered zongzi has two flavors, mango and durian. It’s called zongzi, but it’s actually not a traditional zongzi. Just like the ice-covered moon cake, it’s ready to eat without cooking, so it’s very convenient to eat. Of course, it should be better if it’s iced.

Let’s take a look at the mango ice dumplings first. Its skin is transparent, and you can directly see the mango stuffing inside. When eaten alone, it is tasteless, but it is chewy. How can I put it? This taste is not bad.

The mango stuffing inside is rich in flavor, waxy and slightly sweet, but it is barely acceptable to eat with tasteless ice skin. This kind of stuffing is a bit like Zanba, and friends who like sweets should like it.

Durian ice dumplings are basically the same in appearance except for different fillings, and they are also wrapped with very chewy ice skin.

Personally, the taste and mouthfeel of durian stuffing are better than mango stuffing, and the taste is fuller. If you eat durian in one bite, you can try it boldly.

6 Sam stock black truffle cloud leg dumplings

The last finale is Sam’s soup with black truffles and cloud-legged zongzi. This zongzi is mainly flavored with soup with black truffles. It belongs to salty zongzi, with a single weight of 110g.

At first glance, the materials used in this zongzi are absolutely solid, including pork belly, lotus seeds, ham, egg yolk, black truffles and some fungi. It feels like a zongzi that integrates many delicacies. The addition of broth and black truffles makes this zongzi smell very fragrant, which makes people want to eat it right away.

It tastes very layered, and it combines the flavors of various delicacies. It smells so fragrant that there are no friends. I want to eat a second bite after eating one, and I can’t stop. If you like salty meat zongzi, try this zongzi, and it will definitely satisfy your appetite.

summary

These are the novel dumplings I shared this time. No matter whether they are sweet or salty, the taste is not bad. If you are tired of eating traditional dumplings, you can buy some and try them, and maybe you can explore a new world of your taste buds. What other novel flavors of zongzi have you eaten? Welcome to share in the comment area.

This article comes from what is worth buying website (www.smzdm.com).

1905 movie network news A few days ago, the animated comedy film released its first preview, and DreamWorks’ much-anticipated brand-new animated IP unveiled its mystery! The film is based on the best-selling comics in the world. The senior animator of the series first directed the tube, the ace producer made a heavy effort, and the dubbing stars were shining. The Emmy winners of the Golden Globe Awards gathered to give a voice! This film is scheduled to be released in North America on April 22nd, 2022.

The League of Bad Guys is adapted from the popular comic book of the same name. Its original work has been published in 16 million copies worldwide and has been on the authoritative bestseller list for more than 120 weeks. This time, it is re-presented in the form of a movie, and the "bad guy style" is about to sweep the big screen. In the notice released today, five "bad guys" who commit all kinds of evils — — The handsome pickpocket "Big Bad Wolf", the well-informed safe thief "Greedy Snake", the calm and calm camouflage master "Beautiful Belly Shark", the irritable thug "Piranha" and the glib hacker expert "Hacker Spider" appeared on the scene. They are the most notorious "bad guys alliance" and have committed numerous robberies over the years. However, as the world’s most wanted gang, it decided to become a model citizen? Is this a deception or a sincere repentance? An unexpected and hilarious hilarious adventure was staged, which can be said to be full of expectations.

It is worth mentioning that the behind-the-scenes lineup of this film is very strong. Director Pierre Perifil is famous in the industry for his participation in the animation production of Kung Fu Panda series films. In addition, he also served as an animator for Shrek 4 and other films. In 2019, the animated short film "Rabbit Ear Bag Beaver" directed by him was shortlisted in the top 10 best animated short films of Oscar. Damon Ross and Rebecca huntly, the gold medal producers of DreamWorks, are escorting the film. They have been engaged in the development and production of many animations such as The Boss Baby’s Magic Hair Elf, which can be described as rich experience. In addition, the dubbing lineup of this film is also worth looking forward to. Many powerful actors, such as Oscar for Best Supporting Actor, Golden Globe Award for Best Actress in Movies-Musical Comedy, and Emmy Award for Best Supporting Actress in Comedy Series, poured their hearts out. They have different styles, but they cooperated seamlessly. The regrouping of the "Bad League" will surely bring a wonderful story of ups and downs, laughter and tears.

In addition, as a brand-new IP of DreamWorks, this film is not limited to the original, but has been re-created on the basis of inheriting the iconic elements in the book, as director Pierre Perifil said: "We have built a new story, but we are still faithful to the characters and related experiences in the original." Impressively, in the preview, the cool racing scene and the fierce action drama can be described as very eye-catching. In order to create the most distinctive picture, the film draws a lot of inspiration from animated films from different countries, and combines the action scene with the humorous interest in character design and animation style, and finally presents a happy and charming effect. The director bluntly said: "Our action scenes in this movie are very special, and you will never forget them!"

In 2022, "League of Bad Guys" will be released with laughter, so stay tuned!

　　This year’s 23rd tropical storm "Fete" weakened into a tropical depression at 9 o’clock this morning in Jian ‘ou City, Fujian Province. At 9 o’clock, its center was located at 26.8 degrees north latitude and 118.4 degrees east longitude, with a maximum wind force of 7 (16m/s) and a minimum pressure of 998 hectopascals.

　　It is estimated that "Fete" will move to the south-west direction at a speed of 15-20 kilometers per hour, and its intensity will continue to weaken.

　　Because the intensity of "Fete" is obviously weakened and the wind force near the center is very small, the Central Meteorological Observatory lifted the typhoon blue warning at 10 o’clock this morning, but its residual circulation will still cause heavy rainfall in Jiangsu, Anhui, Shanghai, Zhejiang, Jiangxi, Fujian and other places. Please continue to pay attention to the subsequent wind and rain impact caused by "Fete".

　　In addition, the No.24 strong typhoon "Danasi" has been strengthened into a super typhoon at 8 o’clock this morning. At 8 o’clock, its center is located on the northwest Pacific Ocean about 850 kilometers east of Taipei, Taiwan Province, China, which is 25.2 degrees north latitude and 130.2 degrees east longitude. The maximum wind force near the center is 16 (52 meters per second), the lowest pressure in the center is 935 hectopascals, and the radius of the 7-level wind circle is 350 kilometers.

　　It is estimated that Danas will move to the north-west direction at a speed of 25-30 kilometers per hour, and its intensity will be maintained or slightly strengthened. From this afternoon to night, "Danas" will move into the southeastern part of the East China Sea.

　　Affected by cold air, Feite and Danasi, there will be 7-9 winds in the southern part of the Yellow Sea, most of the East China Sea, the Yangtze River estuary, Hangzhou Bay, the coastal areas of Zhejiang and Shanghai from this afternoon to tomorrow noon, among which the winds in some sea areas are 10-12, and the winds in the nearby sea areas where Danasi Center passes can reach 13-16; There are heavy rains or rainstorms in central and southern Jiangsu, southern Anhui, Shanghai, Zhejiang, northeastern Jiangxi and northern Fujian. Among them, there are heavy rains (100-150 mm) in parts of northern and western Zhejiang, southeastern Anhui and northeastern Jiangxi.

(Source: Editor of Central Meteorological Observatory: Shi Long)

　　Some time ago, Lu Wei, a graduate of Beijing Institute of Technology, returned to her hometown and became a directional Selected Graduates in Guangxi Zhuang Autonomous Region. Talking about this choice, she said: "With the help of the national funding policy, I successfully completed my studies. I am duty-bound to return from my studies and build my hometown. "

　　Like Lu Wei, thanks to the increasingly sound student financial aid system, more and more students are no longer out of school because of family financial difficulties, but also get incentives for self-improvement and all-round development. The reporter learned from the Ministry of Education that at present, China’s student financial aid has realized the combination of multiple policies of "award, assistance, loan, exemption, diligence, supplement and reduction", with an annual subsidy of 160 million people and an annual subsidy of more than 290 billion yuan.

　　The system is more complete

　　All classes, all schools and all students with financial difficulties from families are fully covered.

　　Fu Huiping was born in a remote mountain village in Hongya County, Meishan City, Sichuan Province. In 2012, her father was accidentally injured at the construction site, resulting in lifelong disability, which made the poor family worse.

　　"Just when we were most embarrassed, the care of the party and the government came quietly." Fu Huiping said that during junior high school, on the basis of the "three exemptions" policy of compulsory education, she enjoyed an annual living allowance of 1,250 yuan for students from poor families and an annual education poverty relief fund of 2,000 yuan. During senior high school, I will enjoy 3,000 yuan of state grants and 1,500 yuan of educational poverty relief funds every year.

　　With the continuous support, Fu Huiping was able to study with peace of mind. Last year, she was admitted to Sun Yat-sen University with excellent results. At the same time, she received a subsidy of 5,000 yuan from 1000 yuan and Yucai Education Foundation for freshmen, and applied for a student loan.

　　"Along the way, I remember everyone who helped me and every student fund." Fu Huiping said: "I want to turn care into the driving force to move forward, study hard, and pass on love and hope."

　　To protect people’s livelihood and warm people’s hearts, student financial assistance is related to education equity and people’s livelihood well-being. In recent years, from the establishment and implementation of the pre-school education funding system, to the exemption of tuition and miscellaneous fees for students with financial difficulties in ordinary high schools, to the establishment of national scholarships for secondary vocational schools, and the introduction of national funding measures for college students to enlist in military service, the scope of student funding has gradually expanded and the scale has steadily increased, achieving three full coverage of the funding policy "all classes, all schools and all students with financial difficulties in families".

　　Not long ago, the Notice on Adjusting and Perfecting the Relevant Policies of Student Loans was issued, which clearly stated that the maximum loan amount per student per year of national student loans would be increased by 4,000 yuan, the interest rate of national student loans would be reduced by 30 basis points, and the commercial student loans for graduate students would be carried out at the same time. The relevant person in charge of the Ministry of Education said that with full consideration of China’s economic and social development and the changes in students’ needs for assistance, the funding policies for each school section will be gradually improved.

　　"China’s student financial aid policy system includes not only the policy of helping the poor, but also the policy of rewarding the excellent and encouraging and guiding. The introduction, adjustment and improvement of each financial aid policy have been fully investigated and demonstrated, which not only draws lessons from international common experience, but also considers China’s economic and social development, and strives to solve the urgent problems of the people, fully demonstrating the characteristics of China." Ding Xiaohao, a professor at Peking University Institute of Education, said.

　　Help is more accurate

　　Big data analysis has become a staff assistant for student financial assistance.

　　Li Yafeng, from Zhangbei County, Zhangjiakou City, Hebei Province, was both excited and anxious when he received the admission notice from Xi ‘an Jiaotong University: "There was a rainstorm and flood disaster this summer, and our family suffered serious economic losses. I don’t know if I can apply for a difficult subsidy in a situation like mine? "

　　When I was at a loss, the phone call from the school counselor solved the urgent needs of Li Yafeng’s family. "Before entering the school, the teacher gave me a detailed introduction to the funding policy, and guided me to apply for a special subsidy for disaster relief and apply for a student loan. At the time of registration, students will be admitted through freshmen ‘ Green channel ’ I entered school smoothly, and the school also distributed necessary daily necessities such as mattresses. " Li Yafeng said that these cares made him feel very warm.

　　In the process of student financial aid, how to ensure that no one is left behind, that no student is dropped out of school because of family financial difficulties, and how to put every penny into practice and play its role? "Accuracy" becomes the meaning of the title.

　　"Precision funding should be supported by informationization, so that data can become a staff assistant for student funding." Sun Zao, deputy secretary of the Party Committee of Xi ‘an Jiaotong University, introduced that the school has set up a big data analysis and service platform, comprehensively opened up the business systems of 16 departments, including academic work, teaching, enrollment and employment, and built a multi-dimensional and full-cycle growth file for students, so as to accurately depict students and accurately identify the aided students. For abnormal situations such as sudden changes in consumption habits, decline in academic performance, irregular attendance and rest, through early warning information, counselors and class teachers are reminded to follow up in time to carry out difficult subsidies, academic counseling, employment counseling, psychological assistance and other related work.

　　Accuracy is the inevitable requirement and the basic method of student financial aid. Henan province has fully implemented the national funding system, implemented the data periodic reporting system, realized the informationization of funding management, and also developed a facial recognition supervision system to promote the funding into the "one card" distribution of benefiting the people and farmers; Peking University opened the Yanyuan sailing project to help the funded students in a grid way, so as to realize the cross coverage of the financial aid managers and sailing instructors for students with financial difficulties; Zhongnan University of Economics and Law encourages faculty and staff to integrate home visits of poor students into work such as out-of-town investigation, exchange and discussion, social practice, etc., and strive to improve the accuracy of the identification of funded objects … … Schools around the country take measures to ensure that student financial assistance is fairer and more efficient.

　　"Starting from formulating the basis for identification, refining the working procedures, and establishing a comparison mechanism, we can accurately identify the aided students, find the accurate base, use technical means to carry out smart funding, and use big data analysis to carry out invisible funding. Nowadays, the accuracy and timeliness of the implementation of student financial assistance policies have been significantly enhanced." Ding Xiaohao said.

　　Cultivate more comprehensively

　　Attach importance to the improvement of students’ comprehensive quality and ability

　　Some time ago, Liu Liwen, a student of Beijing University of Posts and Telecommunications, participated in a theme social practice that impressed him deeply. During the 10 days, the team members came to Tibet, made an investigation in the border villages in Lajiao Township, Luozha County, carried out patriotic propaganda in rural primary schools, and patrolled the border with border guards and border guards … …

　　"I come from a remote township in Sichuan. As a beneficiary of the student financial aid policy, I have the opportunity to come to the frontier and witness the development, changes and prosperity of the motherland. I am very grateful to the country and the school, and I will work harder, be more tenacious and be more active in my future study and life." Liu Liwen said.

　　"It is one of the important goals of our student financial aid work to let students enter the society, go deep into the front line, understand the national conditions and people’s feelings, and cultivate the feelings of home and country." Alice Chan, director of the Financial Aid Center of Beijing University of Posts and Telecommunications, said that the school has gradually established an all-round and diversified financial aid and education system to ensure that every aided student has a secure life, motivation to learn and a platform for development.

　　In recent years, student financial aid has gradually extended from security to development, and the aided students have developed in an all-round way. Schools all over the country integrate socialist core values into scholarship selection, grant application, student loan handling, work-study and other links, carry out in-depth inspirational education, gratitude education and honesty education, focus on cultivating students’ spirit of striving for Excellence, glorious consciousness of labor and self-improvement quality, and guide students to establish a correct outlook on success, employment and values.

　　At the same time, under the guidance of the subsidy policy, "solving difficulties — Educating people — Become a talent — A virtuous circle of feedback has gradually taken shape. Hundreds of thousands of aided normal students have devoted themselves to rural basic education, which has improved the quality of rural teachers; A total of 750 thousand college graduates have taken root in the central and western regions, hard and remote areas and old industrial bases, optimizing the structure of grassroots cadres and professionals; A total of 1.76 million people have enjoyed state funding for military service (including direct recruitment of non-commissioned officers), which has promoted the modernization of national defense and the army.

　　"Student financial aid must adhere to the people-oriented principle. While doing a good job in economic assistance and life assistance, we should pay more attention to students’ quality training and ability improvement, give more support and help in study and study, provide and create more opportunities in social practice, and provide more guidance and help in employment and entrepreneurship." The relevant person in charge of the Ministry of Education said that it should be a higher pursuit of student financial assistance to make every child grow into a talent and realize his life dream.

　　(Zeng Yuxi participated in the writing)

　　The brand positioning is scene intelligent electric vehicle. Before the car was experienced, this positioning was relatively conceptual. However, after the test drive of this iCAR 03, I really realized the technical cohesion of this "science man" for the ultimate scene, which is not limited to the elevation of the black technology software of the car, but also can put the high-level off-road ability that A-class pure electric city SUVs dare not play into iCAR03. I really didn’t expect that the seemingly "harmless" iCAR03 is not just as simple as a household electric car, but also has great achievements in the all-terrain field, such as easily climbing the 38-degree high slope, easily climbing the stairs, easily passing through the cross shaft, easily passing through the water pool mixed with ice fragments, etc., making cross-country very easy, which completely subverts people’s cognition of iCAR brand and always thinks that it is just a scooter.

　　After the off-road venue, I really feel that the brand’s promotion to iCAR03 is too conservative, and it is not as simple as "electric tidal box SUV".

　　Simple appearance but not simple

　　Last year was the year when China brand launched more square box-type off-road vehicles. Although iCAR 03 is also a square box shape, it is difficult for you to directly associate it with off-road vehicles and hardliners. However, if you look closely, there will be a ""content in the profile of the side body. However, in addition, the appearance of iCAR 03 is more original lines.

　　ICAR 03′ s external dimensions are 4406mm long, 1910mm wide, 1715mm high, and the wheelbase reaches 2715 mm. The overall shape is very square, and the tough body contour is outlined by using very geometric lines, which is friendly to the interior space.

　　The shapes of the light groups at the front and rear of the car are consistent, and they all use the shape of the "I" digital intelligent light group. The shapes of the front and rear light groups echo each other, and also echo the iCAR logo. The front lights have six kinds of intelligent lights, and the overall shape is relatively simple, but it has a high recognition rate. However, this kind of thing is definitely different for individuals.

　　The shape of the square box is simple, but the details are not simple. In addition to the small intention of the light group, iCAR03 uses an electric hidden door handle, which has an ice-breaking power of 120N in the snowy winter.

　　The appearance details are also reflected in the four-wheel eyebrow lights, all of which are embedded with "I-mark lights". This design is rare in other models. It can be said that the iCAR brand is very careful in increasing vehicle recognition.

　　In addition, there are two details: the design of iCAR at no cost. One is that the rear tailgate is opened at a 90-degree right angle only by hard-core off-road vehicles, in order to take things more conveniently. On this side tailgate, there is also an electric suction door, which can be automatically sucked with a slight clearance, so as to achieve the same configuration as the mainstream off-road vehicle, which not only saves worry and effort, but also from this aspect, the positioning of this model has slowly leapfrogged.

　　In addition to the tail door full of off-road flavor, a real small schoolbag was designed at the tail. In the past, off-road vehicles were called "small schoolbags" when they took a spare tire, but iCAR03 really installed a small schoolbag with Chaochuang personality, which can realize the wet and dry separation of take-away items. Press the point I in iCAR to open it, which is really intimate.

　　In terms of details, not only these, iCAR0 3 also has 50KG load-bearing luggage rack, 220V3.3kw external discharge, 1.6T traction qualification and 12V power supply in trunk. ICAR 03 adds a series of hardware for off-road, home and tide play, so that users can travel/drive with ease.

　　Interior Configuration of Intelligent Equal Rights

　　We see that the simple but not simple appearance is amazing, and the interior, configuration and intelligence are even more simple. The interior style of iCAR 03 has two colors: dark and light. It is expected that most users will choose the light interior because it is elegant, and the patchwork and rough outline make the interior style unique in the compact pure electric SUV.

　　The center console is equipped with two screens, a clear digital instrument screen and a 15.6-inch ultra-wide field of view central control large screen. The two screens have a clear division of labor, and for an A-class pure electric SUV, it can fully meet the demand.

　　ICAR 03 comes standard with Tencent Ecology, which meets the requirements of multi-instruction parallelism such as driving directions and entertainment. It has four-tone language control recognition, which can accurately identify the instructions issued by passengers from different locations, and the control is more intelligent and accurate. As well as full-scene voice control, greatly liberating multi-command control with both hands.

　　It can also expand mainstream APP applications, and its menu catalogue and function card design are easy to understand, and the pull-down shortcut function and air conditioning control are very intuitive.

　　It is worth mentioning that the intelligent cockpit of the four-wheel drive model adopts the 8155 chip, which can support the smooth playback of 8 channels of 4K video, and the 360 image and voice interaction function is supported by the 8155 chip to achieve the first-class in the same class. ICAR 03 also supports more than 20 intelligent modes such as pet mode, nap mode, karaoke mode and child lock mode.

　　In terms of audio and video configuration, this model is also the "top" configuration in the same level. The Infinity Swallow Lishi audio system equipped with 12 high-performance speakers above the four-wheel drive long-life advanced version has been professionally tuned by Harman Kardon.

　　In terms of technology configuration, it can be said that everything this handlebar can give is in place. For a model of 120,000-180,000 yuan, its configuration is rich and reasonable. In this respect, I have to admire Chery’s pursuit of cost control and technology.

　　Efficient power and reasonable configuration.

　　The power part of iCAR 03 is relatively mainstream, but in the mainstream, there is unexpected potential to be stimulated. The model of this test drive is a four-wheel drive version, equipped with dual-motor power, with a peak power of 205Kw, a wheel torque of 4100N·m, and an acceleration of 6.5s per 100 kilometers. The electric drive is a six-in-one flat-wire motor with the highest efficiency of 96.96%, which has the characteristics of high energy, high efficiency and low consumption.

　　As for the power battery, Contemporary Amperex Technology Co., Limited’s customized battery core is adopted, which has the characteristics of high energy density. In terms of battery cell energy density, the two-drive version is 401: 180.9 Wh/kg; Two-wheel drive 501 version is 182.19Wh/kg；; The version of the four-wheel drive 501 is 182.19Wh/kg, and the energy density of the 501 battery life package reaches 139wh/kg.

　　For battery protection, iCAR 03 adopts a "sandwich" structure with a 10mm battery protection armor body. The upper and lower versions of the battery pack are made of aviation grade material, the upper case is covered with 1000°C ultra-high temperature resistant mica material, and the lower case is made of aluminum alloy plate, which can achieve a pressure of 20kPa.

　　ICAR 03 has inherited Chery’s profound technical innovation ability in the aspect of three power plants, and has a long-term vision from capability to safety to sustainable use. For example, in terms of body structure and chassis, in order to enhance strength and reduce unsprung weight, iCAR has created a hybrid super-strong chassis, using a 3,500-ton integrated die-casting tower top structure and an all-aluminum honeycomb structure girder to form a super-rigid foundation. Hollow cast aluminum H-arm is adopted in the chassis structure of H-arm multi-link and hydraulic bushing, which reduces the weight by 30% and the unsprung impact.

　　In terms of body frame, it’s really worth saying more, because its body-in-white weighs only 230kg, which is not as heavy as an adult pig. In addition, the original all-aluminum multi-cavity cage body makes the curb weight of iCAR03 only start from 1.68 tons, which is a pure electric vehicle, and this innovation has laid a deep foundation for off-road ability.

　　Comfortable city driving

　　ICAR 03 with square box shape has advantages for riding experience, with ample head space and leg space brought by 2715 wheelbase, which is enough for a family of three to travel. The effective space utilization ratio of iCAR 03 vehicle reached 66%, and the interior space reached 64.3%.

　　The car has a super-large rear head space of the same level. According to official data, the rear head space reaches 991mm, which makes passengers’ activities in the car not cramped.

　　In terms of storage space, the whole vehicle has several extensible storage spaces, including the storage bin under the 24L rear seat and the backup storage space, which can be extended to 1238L.

　　In normal pavement driving, the acceleration of iCAR 03 is very rapid, and the required driving mode can be selected through the driving mode on Nakajima. iCAR 03 has 8+x all-road driving modes to choose from, and there are four modes to choose from on paved roads: energy saving/comfort/sports/personalization. If it is a four-wheel drive vehicle, the four-wheel drive and two-wheel drive will automatically switch during normal driving, which will bring more energy-saving performance.

　　For the iWD intelligent electronic control four-wheel drive equipped with iCAR 03, the performance on the pavement is very smart, and it will remain in the two-wheel drive mode most of the time, and will switch to the four-wheel drive only at the moment of starting and accelerating, and once the vehicle maintains a stable power output, it will remain in the two-wheel drive output.

　　ICAR 03 adopts the design of arms, which is very convenient when switching gears, moving forward and backward. When turning left and right, the central control screen will open the camera on the steering side to make up the blind spot, thus achieving a safer purpose.

　　Because the weight of the car body is the same as that of a fuel car, the starting and acceleration of iCAR 03 is very easy. Although it is also an electric car that has a smooth sense of acceleration, it is obvious that the support of the chassis is very resilient, and when turning at high speed, the control of the car body is very dexterous, and there is almost no inertia brought by the dynamic potential energy. The direction of the steering wheel is completely unified with the direction of the car body.

　　For the transmission of road conditions, iCAR 03 can transmit the road conditions as delicately as golf, especially the feeling between roads, potholes and gravel roads is relatively clear, the suspension is well supported, the resilience of shock absorption is obviously very tough, and there is room for accepting greater impact.

　　Generally speaking, the adjustment of iCAR 03 on paved roads is conservative, and it is mainly for the comfort of family cars, but it is not very radical. On the one hand, it shows that iCAR03 is positioned as a home and trendy car, not a performance car. However, the performance is not reflected in the pavement, but it is completely released in the off-road field.

　　Many cross-country events are not to mention.

　　Who would have thought that although the appearance of iCAR 03 has the value of "harmless to people and animals", playing in off-road venues, I think many hard-core off-road vehicles that sell more than 300,000 will not underestimate it. This off-road test drive was carried out on a site with a slope of 38 degrees. Seeing the models that don’t take off-road as the selling point, it’s really a sweat to challenge many hard-core off-road test sections, or I don’t have much confidence in iCAR 03.

　　However, the display is very cruel. iCAR 03 completely hit the face, not only with a 38-degree slope, but also with a cross shaft and a wading pool. Even the wheels will not slip, just adjust the corresponding driving mode in the car.

　　ICAR 03 can be regarded as a real software-defined car. Some SUVs that also use dual motors are just competing for acceleration time, but iCAR 03 makes it too easy for hard-core off-road to complete. When climbing a hill, you only need to stabilize the speed and look at the transparent body and direction displayed on the hollow screen, even without adjusting to any off-road mode.

　　After reaching the top of the slope, adjust the mode to flexible downhill, release the switch and brake, and the vehicle will firmly grab the ground and descend to the ground very stably, which makes the novice cross-country very calm. The difference between flexible downhill and steep slope descent is that the software is used to calculate the adhesion of each wheel, the slope data and the vehicle speed, and the torque release of each wheel is controlled more subtly, and the vehicle speed is controlled by a motor, instead of controlling the downhill vehicle speed to a set value in general.

　　With the difficult uphill as the foundation, it is actually easier to pass when facing the challenges of climbing stairs, small humps and narrow bridges.

　　What I didn’t expect was that iCAR 03 passed easily when it challenged the 30cm cross axle. We can see that when it crossed the axle, sometimes a wheel would be suspended and have no adhesion. At this time, IWD’s intelligent electronically controlled four-wheel drive can distribute the dynamic torque of the front and rear motors, start the wheel with millisecond-level response, and instantly increase the torque of the wheel with adhesion, so as to achieve normal passing. This does not require particularly high driving skills, just need.

　　What is even more surprising is that when many friends recommend various in-situ U-turn functions in a high-profile manner, iCAR 03 also has the ability of extreme turning, that is, after the steering wheel hits a certain side, the rear wheel will lock with the direction, forming a compass leg mode, dragging the vehicle to extreme turning, thus reducing the turning radius. In order to achieve this turning mode, you only need to select the extreme turning mode in the screen.

　　To sum up, the off-road capability of iCAR 03 is an unexpected bright spot, so that it masks its trendy nature. As the first model of iCAR brand, iCAR03 can definitely be called a pure electric compact SUV with a new height of "involution". If you are a cross-country enthusiast and just want to have a drink in the surrounding cross-country, iCAR 03 is a very good choice, and its price is still within 190,000, which is great for the cost of playing cars. If you are a user who likes go on road trip and needs daily transportation, the intelligence, comfort, space and expansion ability of iCAR 03 can fully meet your play needs, and it is a good choice for low-cost cars. Therefore, if you are interested in iCAR 03, you might as well go to its experience store to have a look.

The richness of a car configuration is related to the user’s car experience, so many people are concerned about its configuration today. Not much to say, let’s take a look.

First of all, from the appearance, the front face of Model Y has improved the grade of the whole vehicle and looks very sporty. Coupled with the sharp headlights, the grade of the whole vehicle has been improved. The car is equipped with LED daytime running lights, front fog lights, automatic opening and closing, adaptive far and near light, delayed closing and so on. Come to the side of the car, the car body size is 4750MM*1921MM*1624MM, the car uses sharp lines, giving people a very tough feeling, with large-sized thick-walled tires, giving people a very capable feeling. In terms of the rear end, the overall shape of the rear end echoes the front face, and the taillights give people a very tough feeling, and the shape is avant-garde.

Coming into the Model Y car, the interior of Model Y adopts a simple and generous shape, which highlights the layered effect. The steering wheel of the car is well designed and made of genuine leather, which gives people an impulse to control it. Let’s take a look at the central control, with a 15-inch touch-sensitive LCD central control screen, which makes the interior design quite layered, and the overall design of the central control is remarkable. The dashboard and seats are also eye-catching. The dashboard of this car presents a tough design style and looks very unique. The car adopts leather-like seats, which are wide and thick, improving the riding experience of drivers and passengers.

The Model Y is 357KW, the total torque is 659N.m, and the maximum speed is 250 km/h.

The space performance of the Model Y trunk is OK. If there are large items during the trip, you can put down the rear seats to expand the space. At the same time, the car is equipped with anti-lock braking (ABS), LED daytime running lights, brake assist (EBA/BAS, etc.), braking force distribution (EBD), traction control (ASR/TCS, etc.), main driving airbag, co-pilot airbag, side airbag curtain, front side airbag and other safety configurations.

Do you have the urge to buy a car after reading the whole article? Let me make a summary. This car has been introduced almost before, and I believe many users who buy a car have taken a fancy to its comfort and practicality.

This article comes from WeChat WeChat official account:CC weekly (id: cancer-weekly), Author: Zhang Yujiao (tenured professor of The University of Texas MD Anderson Cancer Center), original title: "Exclusive | These five groups of people cannot be vaccinated! Chinese scholars analyze the top ten problems of Pfizer vaccine, with the title from vision china.

Core summary

1. On the 10th local time, the US Food and Drug Administration（FDA）With 17 votes in favor, 4 votes against and 1 abstention, COVID-19 Vaccine Group decided thatThe benefits of using Pfizer /BioNTech COVID-19 vaccine in adults aged 16 and over outweigh the known risks, and the COVID-19 Vaccine Team of FDA recommended that Pfizer’s COVID-19 vaccine be approved.This means that the last obstacle has been cleared before the COVID-19 vaccine goes on the market in the United States.

2. The vaccination effect of tumor patients receiving chemotherapy and radiotherapy and patients undergoing bone marrow and organ transplantation needs to be studied. People who have been infected should also be vaccinated, but it is not recommended for pregnant women to be vaccinated. Patients with a history of severe allergies should also be carefully vaccinated.

3. At present, it can only be concluded that COVID-19 vaccine is valid for more than half a year.As for how long, we have to wait for the data to speak. According to the current state(Including the titer and maintenance of antibodies in early studies)It may be a year or so, I hope it will be longer.

4. The extent to which COVID-19 vaccine can reduce the chance of spreading virus after vaccination needs further study. Therefore,After vaccination, you need to wash your hands, wear a mask and be socially isolated.

On December 8th, the world’s first Pfizer COVID-19 mRNA vaccine was inoculated in the UK after the third phase clinical study confirmed its effectiveness. The 90-year-old lady told the media at the vaccination site with a strong British accent: "This is the best thing that has happened to me, both effective and free!" . The second vaccinator is an 80-year-old man. His name is William Shakespeare, and he has the same name as the great British writer.

On the same day, after three weeks of investigation, FDA issued a review statement: Pfizer vaccine has no safety concerns, and the effective rate can reach 52% after the first vaccination, and the effective rate will rise to 95% after the second vaccination, and the vaccine can significantly reduce the number of critically ill patients. FDA(US Food and Drug Administration)Decided to submit it to the expert Committee on vaccine efficiency and safety outside the FDA for public hearing, and the whole hearing will be broadcast live on national television.

By 30 FDA independent committees on vaccine efficiency and safety(composed of vaccine experts, doctors and representatives of the public)The hearing will be held from 9: 00 am to 5: 45 pm on December 10, US Eastern Time and December 11, Beijing Time.(Tubing, live broadcast by Twitter). Members of the Committee reviewed tens of thousands of pages of information in advance. After a heated debate, 17 votes in favor and 4 votes against the emergency use of Pfizer mRNA COVID-19 vaccine for adults over 16 years old.

At the hearing, Pfizer released detailed data for the first time. People over 16 years old, including those over 55 years old, have chronic diseases.(including heart and lung disease, cancer history)Those who have a history of HIV, HBV infection but have been controlled are all enrolled in the third phase of the study.

About side effectsMild to moderate discomfort at the inoculation site is very common. Moderate systemic reaction is about 18%, and serious side effects are less than 5%. The research is still going on, and the FDA requires Pfizer to submit updated information to the FDA in January until two years later.

About efficiency95% of the total protection efficiency occurred 7 days after the second inoculation. The protection efficiency of people of all ages and races is above 93%. It has a good protective effect on the history of basic diseases, including cancer.

At the hearing, the safety hazards such as patients with obvious immune deficiency, patients with severe allergic reactions, pregnant women and children were discussed. At the same time, the possibility of transforming mRNA into DNA and reducing the possibility of human-to-human transmission are discussed, and suggestions for future research are put forward, including further research on asymptomatic infected people.

The most controversial issue is whether teenagers aged 16 and 17 can be vaccinated, because there are only more than 100 people in this group in the study.. Some members are opposed to vaccinating teenagers aged 16-17, which is the main reason for voting against it. However, the FDA insists that because many 16-and 17-year-old children in the United States have started working in supermarkets, it is more dangerous.

On December 17th, another mRNA vaccine(Moderna Modena)An FDA hearing will also be held and approval is expected.

After nearly a year of long suffering, people finally saw the dawn. The British media said that "we are vaccinated with hope". However, in the face of more than 1.5 million lives lost around the world, we can’t help but sigh "too late". However, it is worrying that more than 37% of the American people are not willing to be vaccinated at present. They questioned"So soon? Is it safe? ！”

Take the United States as an example. Up to now, more than 15 million people in the United States have been infected with COVID-19, and nearly 300,000 people have lost their lives. The second wave of epidemic has just broken out in autumn and winter. Recently, there are 200,000 new cases and more than 2,500 deaths in the United States, far exceeding the first wave in July this year! At this exponential growth rate, if there is no vaccine and effective social isolation, the probability of each American being infected in 2021 will exceed 50%! Each of us should ask ourselves, should we be vaccinated, infected naturally, or locked up at home?The answer is obvious, we have no choice!

At present, nearly one million people have been vaccinated with four vaccines in China. However, the side effects of Pfizer vaccine, such as severe allergy, and whether some immunocompromised people, such as children, cancer patients, organ transplants, pregnant women and AIDS, can be vaccinated, and who can be vaccinated, have also become consistent issues and choices faced by China and the United States. However, the problems encountered in the vaccination of Pfizer vaccine and Modana vaccine in the United States and the United Kingdom will also serve as a reference for the China vaccine that will be widely vaccinated in the future.

First, who will be vaccinated first? What is the final goal?

According to the discussion results of CDC on November 30th, the order of COVID-19 vaccination is as follows:

First batch(From 15 December): frontline medical staff(20 million)And the elderly in nursing homes(millions).

So far, Pfizer will provide 40 million doses of vaccine before the end of the year; Moderna will provide 20 million doses before the end of the year.

Second batch(From January next year)Social necessities, including police, postmen, firefighters, dieters, school teachers, cleaners, food processors, etc.(nearly 90 million). Old people over 65 years old(fifty million).

The third batch: ordinary people(From March next year)It is estimated that more than 100 million people.

The fourth batch: young people and children under the age of 16(From May next year): tens of millions.

MD Anderson medical staff were among the first to be vaccinated. The hospital has subdivided the first batch of personnel:

At present, the Texas government has announced the distribution number of the first batch of Pfizer vaccines in major hospitals. MD Anderson Hospital will receive nearly 5,000 doses of COVID-19 vaccine on the 14th.(two doses for one person), should be able to supply all the clinical medical staff of 1a with vaccination.(The hospital has nearly 1,000 full-time doctors, more than 20,000 full-time employees, and nearly 30,000 people for further study.).

Goal:Strive to reach 70% vaccination rate after June next year, and promote group immunization.(95% effective rate x70% vaccination rate =66.5% immunization rate). In other words, we should stick to wearing masks and social isolation until the end of June next year.(Biden asked people to hold on at least until the end of April). Clear goals, but a long way to go! What should developing countries do if developed countries plan like this?

Figure/COVID-19 vaccine samples developed by Pfizer and BioNTech.

Second, should cancer and other patients with immunodeficiency, or people with severe allergies be vaccinated?

Should cancer and other patients with immunodeficiency, or people with severe allergies be vaccinated? At present, in the third phase of clinical research, tumor patients receiving chemotherapy and radiotherapy, or patients with bone marrow and organ transplantation, HIV, etc., are not allowed to participate in the study because of potential immunosuppression. Therefore, the effect of these patients after vaccination is still a research problem. Related research is being prepared.Generally speaking, if radiotherapy and chemotherapy have stopped for more than one year, cancer patients can consider vaccination.

In addition, two cases of obvious allergic reactions occurred in the population vaccinated in the first week in Britain. Therefore,Experts warn patients with a history of severe allergies to be carefully vaccinated.

3. Should children and pregnant women be vaccinated?

In the current clinical study, neither pregnant women nor children under 12 years old were enrolled. Therefore,Vaccination for pregnant women is not recommended at present. As for teenagers and children(under 16 years old)No further data on safety and effectiveness will be available until May next year.

Fourth, should people who have been infected with COVID-19 be vaccinated?

For people who have been infected,Because the recently reported cases of secondary infection and natural immunity may only last for 3 to 6 months, and the immunity produced by natural infection is weak, they should be vaccinated.

5. How long can immunity last after vaccination?

Since most of the third phase of vaccine research began in July this year, the longest observation time is less than half a year. Therefore, we can only conclude that the validity period is more than half a year at present. As for how long, we have to wait for the data to speak. According to the current state(Including the titer and maintenance of antibodies in early studies)It may be a year or so, I hope it will be longer.

6. After vaccination, will it spread the virus to others? Do you still need to wash your hands, wear a mask and be socially isolated?

At present, the effective rate of mRNA vaccine is 95%, which means that the difference between the number of patients with symptoms accounts for the percentage of the number of patients with symptoms in the control group compared with the random control group that did not receive the vaccine. This is a standard algorithm widely accepted by epidemiology, and it is also a standard index of vaccine listing in the international community, not an invention of a manufacturer. Both Pfizer and Mardner’s vaccine trials rely on patients’ self-reports, and subsequent confirmation tests will only be conducted if there are related symptoms. Therefore, this calculation does not include asymptomatic patients; Secondly, the difference between the two groups in transmission to others has not been detected yet.

Can the vaccine reduce the chance of transmission to others? Scientifically, it should be, but the degree needs further study. Therefore,After the vaccination, it is not necessary to wash your hands, wear masks and be socially isolated. Let’s stick to it for a while and wait for further data.Moreover, the vaccine is not 100% effective, in case you belong to the 5% ineffective population!

Figure/Relevant data of Pfizer vaccine

7. How many times should I be vaccinated? What are the side effects?

Current vaccines all requireInoculate twice. If you only plant it once, the effect will be greatly reduced. Moreover, there must be an interval of three weeks between two times.(Pfizer)Or around.(Mardner). At the same time, the vaccine from the same manufacturer must be vaccinated, even though they are all mRNA vaccines.

As for the side effects, it is a three-point poison. It is an ideal to cure all diseases without side effects; More accurately, it is a fantasy; Be strict, it’s nonsense!

This year, according to the recommendation of CDC in the United States, I have been vaccinated against influenza.(once a year, inactivated vaccine)And herpes zoster vaccine.(Protein vaccine, over 50 years old, administered twice). COVID-19 vaccine is expected to be vaccinated in late December. I don’t have much discomfort after getting the flu vaccine. However, every time I have been vaccinated with herpes zoster vaccine, I have intermittent fever for more than 24 hours, and sometimes fever also causes my whole body to tremble, and my arm is red, swollen and painful for nearly a week. However, I know that these are normal phenomena and belong to mild and moderate side effects.

Based on the available data, most of the side effects of COVID-19 vaccine last for 1-2 days. Common injection site pain, erythema/redness, or fatigue.（Moderna）9.7%, Pfizer（Pfizer）3.8%, fever, chills, muscle aches（ Moderna）8.9%, joint pain（Moderna） 5.2%, headache　（Moderna）4.5%, Pfizer（Pfizer） 2%。

Long-term side effects need to be followed up in the fourth phase after marketing.

Judging from the information released,MRNA vaccine appears severe(three degrees)The side effect was severe fatigue, accounting for 3.7%. Overall, it is very safe.Mild and moderate discomfort similar to a cold is very common and normal. Please be patient!

Figure/After the first vaccination, patients will get a card to remind them to get the second vaccination on time.

8. Will the new virus mutation affect the effectiveness of the vaccine?

The answer is possible. For example, the mutation rate of influenza virus gene is high, so a new vaccine against influenza in that year should be vaccinated every year. And AIDS has always been because the virus mutates too fast, so far there is no vaccine.

Fortunately, according to the current epidemiological survey, Nature Communications magazine published an article in November this year to study 46,000 cases of COVID-19 virus from different periods around the world, and found that the probability of COVID-19 mutation is relatively low because of its unique proofread inspection mechanism, which is undoubtedly the gospel of the vaccine. At the same time, the mRNA vaccine can be modified according to mutation and then reproduced, which is much easier to operate than the terminal protein vaccine. For example, the gun has been built, just need to modify the structure of the warhead.

9. Why should vaccine storage be at MINUS 70 degrees?

Pfizer vaccine needs to be stored in a freezer at MINUS 70 degrees Celsius for a long time, and it can only be stored in a refrigerator at 2 ~ 7 degrees Celsius for 5 days. Moderna vaccine can be stored for a long time in the freezer at MINUS 20 degrees, and can be stored in the refrigerator at 2 ~ 7 degrees for one month. The reason why RNA is sensitive to temperature is that it is easy to degrade with the increase of temperature. Moderna vaccine is relatively thermotolerant, which may be related to the composition and structure of its lipid carrier. This partly explains that the side effects of Moderna vaccine seem to be a little high.

AstraZeneca’s vaccine is an adenovirus strain, which requires lower temperature and can be stored for half a year at 2 ~ 7 degrees. And is suitable for developing countries.(Note: Freund’s temperature F is used in American charts). However, the comprehensive effective rate of AZ vaccine is about 70%. Subgroup analysis showed that the effective rate of the first low dose group was 90%. However, because this group of people is young.(under 50 years old)And it is not designed in advance. Therefore, it is recognized by the industry as 70% efficient.

Photo/Pfizer is building a "frozen farm" the size of a football field to store vaccines in Kalamazoo, Michigan. Pfizer’s vaccine must be stored below the ultra-low temperature of 70 degrees.

X. Why do Britain and America prefer mRNA vaccine?

On December 2nd, Britain took the lead in approving Pfizer’s vaccine and started vaccination on the 8th. Today, the vaccine has also been approved in the United States, and it is expected to start nationwide vaccination on the 15th. On the 17th of next week, the FDA of the United States is very likely to approve the mRNA vaccine of Moderna, and it is possible to start vaccination on the 22nd. Apart from the fact that these two viruses first completed the phase III clinical randomized study, what factors made the world look at the mRNA vaccine with new eyes?

Thirty years ago, I transferred from tumor immunology research to a brand-new field of tumor gene therapy. At the MD Anderson Cancer Center in the United States, my colleagues and I spent seven years constructing a retrovirus, adenovirus and nanoliposome-mediated anti-cancer gene transformation mode and animal tumor model, which not only contributed to the first patient’s cancer gene therapy in human history, but also made a Nasdaq-listed company. I have published more than a dozen papers myself, won two patents for gene therapy, and obtained a doctorate in tumor biology within four years. After that, I decided to return to the clinical front line and started five years of standardized training for clinical oncology residents.

Retroviruses have the longest gene transformation rate and maintenance time, but unfortunately they will be integrated into the DNA of human hosts. Some scholars are worried about the possibility of cancer. At present, this gene transformation method has been rarely used in cancer treatment.

Adenovirus will not be integrated into human DNA, but it is toxic to cells and will cause immunity to adenovirus vectors. This may explain the side effects of AstraZeneca COVID-19 adenovirus vector vaccine and the change of the initial dose to the effective rate.The high dose of the first vaccination may stimulate a stronger immune response against adenovirus vector, which may affect the results of the second vaccination. Therefore, it is better to use a low dose for the first time).

However, nanotechnology liposome itself has little influence on the immune system, and the general mRNA will not be reverse transcribed and integrated into human DNA, but it will express the protein to be transmitted in human cells for a short time.(For example, COVID-19 spinous protein activates the immune response and then gradually subsides), the best security. However, I used DNA plasmid at that time; Because DNA is much more stable. At that time, everyone knew that RNA extraction and preservation were very difficult, and there was no precedent for successful transformation of mRNA gene.

Gene transfer with COVID-19 spinous protein mRNA as the main body mediated by lipid carrier can avoid errors and potential side effects in the process of DNA transcription, so that spinous protein can be efficiently expressed in human cells in a short time, and the immune response of the body can be activated, which can produce specific antiviral antibodies and immune killer cells more effectively than natural infection. Although the gene expression is short-lived, activated B cells and T cells have their own memories, which can destroy or inhibit the virus for a long time. At the same time, this mRNA will not reverse transcribe into DNA, and will not be integrated into the host DNA, which is safe and reliable.

For decades, the method of mRNA gene transfer has been a dream of scientists. Katalin Kariko, the founding partner of Moderna, the inventor of mRNA technology and a Hungarian-born American scientist, has been on the bench for 40 years, and was originally prepared to set up Moderna to engage in mRNA cancer vaccine. As a result, a Cheng Yaojin COVID-19 was killed halfway.

When scientists in China announced the gene sequence of COVID-19 on January 10th this year.(including spinous process protein)Later, the researchers in the United States and Germany changed hands, but they were unwilling to plant flowers and flowers. Fortunately, this spinous protein was finally proved to be a good immunogen of COVID-19, and COVID-19 mRNA vaccine appeared on the scene. This is an important breakthrough in human science and technology, and it is also the result of the joint efforts of scientists from all over the world.

In contrast, inactivating virus vaccine is a mature method, and this traditional method is adopted in the annual influenza vaccine. Its research and development success rate is high, so it is widely used. However, it is difficult to control the temperature during inactivation, which brings some difficulties to quality control. Therefore, the production capacity is limited. At the same time, the added chemicals will also bring some side effects.

Generally, the effective rate of inactivated influenza vaccine is between 50% and 70%. At present, the early toxicity and antibody positive rate of domestic COVID-19 vaccine with inactivated vaccine as the main body and adenovirus vector have been reported. Volunteers can tolerate mild and moderate side effects, and the antibodies are positive after injection. However, positive antibody does not guarantee that it has sufficient protection. The effective rate must be obtained in the three-phase randomized study with control group. Because the epidemic situation in China is well controlled, the corresponding research must be carried out in other countries with high incidence.

Up to now, the epidemiological efficiency of the strict phase III clinical randomized study of vaccines in China has not been reported, and the world is eagerly awaiting it. I believe the final conclusion will be heard in the near future.The advantages of inactivated vaccine and adenovirus vector vaccine are that they are less affected by temperature, easy to store and transport, and more suitable for developing countries.

Due to the potential advantages of technological innovation and high antigen purification and expression, such as improving vaccine efficiency and productivity and reducing side effects, when the effective rate of mRNA COVID-19 vaccine reached 95%, the industry unanimously hailed this major breakthrough. More importantly, there are almost no seriously ill patients among the vaccinators.

Many people think that this is the arrival of God’s grace! Developed countries such as the United States and Britain have booked the products of these two companies in advance. China’s Fosun Company also signed a cooperation agreement with Pfizer and has completed the first phase of clinical trials. It is expected that the related Phase 2 will be launched in China soon.(Non-random)Clinical research to obtain the approval of China FDA.

Figure/A nurse and patient in California. In many parts of the United States, the pressure on the health system has been overwhelmed and is on the verge of collapse at any time.

Although American health insurance and the government will pay the cost of vaccination, another difficulty is that more than 37% people in the United States are not at ease with the vaccine and are not prepared to vaccinate immediately. In this regard, three former presidents of the United States, Bush, Clinton and Obama, said that they would vaccinate under the observation of the media at the first time as a platform for vaccine safety.

Because the vaccine is for normal people, it is not a "medicine", not to treat patients, but to prevent diseases. Meanwhile, for COVID-19 vaccine, the population to be vaccinated is billions of healthy people, including children.Therefore, its safety must be much stricter than that of "medicine".Therefore, if time is not pressing, all new vaccines should wait for a long time.(more than 2 years)The data will be finally approved. But in the face of a serious epidemic, this is irrational. The regulations that allow emergency use are designed for this situation.

At present, FDA requires that the last patient should be observed for at least 2 months after entering the Phase III clinical study to ensure that there are no serious acute side effects. Moreover, regulators must strictly control the use of these new vaccines from the beginning. The initial use of these vaccines is limited to those who need them most-doctors, nurses, other health care workers, and the elderly in nursing homes. Regulators also need to continue to closely monitor the side effects of vaccines already on the market.(so-called Phase IV Clinical Study). With the accumulation of data in the first two months of next year, the range of vaccinators will be further expanded.

The development of human society always strives for survival first, and then for improvement and perfection.

When the hopes of the whole world are pinned on the COVID-19 vaccine, the hardest work has just begun. We know that the best antiviral function of the vaccine will not be realized until two weeks after the second vaccination.In other words, for most people, December this year, January and February next year will be the darkest moments in the medical history of the United States since the Spanish influenza pandemic in World War I.

According to Dr. Fauci, director of the Institute of Infectious Diseases of the National Institutes of Health, it is estimated that by March next year, about 500,000 people in the United States will die in COVID-19, surpassing the number of deaths in World War II in the United States.(about 400,000). Regrettably, some people in the United States still refuse to wear masks and social isolation. Up to now, 37% people are skeptical about vaccines, and the epidemic prevention work has a long way to go!

Controversy over vaccines(Inoculation or non-inoculation, domestic or imported)The reason and background are very complicated, and it will not stop for a while. As a scientist and a doctor, I care most about yourself! Vaccinate, not only for others, but also for yourself!

This article comes from WeChat WeChat official account:CC weekly (id: cancer-weekly), Author: Zhang Yujiao (tenured professor of The University of Texas MD Anderson Cancer Center)

Our reporter Peng Yan

Recently, some banks have adjusted the transaction limit of non-counter channel payment. Many banks, such as Bank of Qingdao and bank of dalian, have successively issued announcements to reduce the total payment limit of some personal accounts through non-counter channels. Among them, Qingdao Bank adjusted the daily limit of some personal accounts to less than 5,000 yuan.

According to the reporter’s understanding, since last year, in order to ensure the financial security of customer accounts, a number of banks have successively adjusted the limits of some customers’ non-counter transactions. What is the specific limit and whether it is limited? Banks make different adjustments to different regions and different customers, depending on the actual use of personal accounts and relevant policies in the region.

According to the historical usage of customers’ bills, Qingdao Bank will take protective measures to reduce the total payment limit of some personal accounts in non-counter channels (including online banking, mobile banking, express payment, self-service teller machines’ ATM’ and consumer terminals’ ‘POS machines’). The so-called non-counter channel refers to the business that is not handled at the bank counter, including but not limited to the business handled through online banking, mobile banking, gateway payment, express payment, POS, ATM, etc.

The Securities Daily reporter called a branch of Qingdao Bank, and the bank’s counter staff said that reducing the total payment limit of some personal accounts in non-counter channels was mainly aimed at restricting transactions in personal bank accounts with no transactions for a long time and low account balance, and adjusting the daily limit to less than 5,000 yuan.

"The risk control for personal bank accounts is tightened mainly to reduce the risk of damage to users’ funds. Because many users have lost their bank cards or have not used them for a long time. " The counter staff of Qingdao Bank told reporters that if the user subsequently applies for raising the limit, the bank will set a reasonable off-counter payment limit after re-evaluation.

Wu Dan, a researcher at China Banking Research Institute, told the Securities Daily that this is an important way to prevent and control bank accounts. It is difficult to confirm the real trading intention of customers for large-value transactions in non-counter channels, and it is difficult for customers to recover once the transfer is successful, so it is necessary to improve the transaction monitoring measures. Identifying customers’ daily trading habits through technical means, conducting customer risk assessment in time, and imposing account restrictions on abnormal operations can effectively protect customers’ "money bags" and give them normal operations when the security signals are sufficient, which greatly improves the quality and efficiency of financial anti-fraud and anti-fraud work.

In recent years, banks have been strengthening the management of personal accounts, from clearing "sleep accounts" to "one-person excess accounts", and then upgrading to include bank cards with balances lower than those in 10 yuan into sleep accounts. In particular, since last year, a number of banks have launched the "broken card" action.

Xue Hongyan, vice president of Xingtu Financial Research Institute, told the Securities Daily that the bank’s adjustment of account limit is mainly based on the need to prevent telecommunication network fraud or anti-money laundering. It monitors the account payment and transfer in real time through the system model, and adjusts the trigger limit for abnormal accounts. In addition, some sleep accounts that have not been used for a long time may also be lowered by the bank and need to be reactivated at the counter.

Wu Dan said that it is equally important for banks to improve the convenience of customers’ transactions and ensure the safety of customers’ funds. It is necessary to continuously improve the ability of account risk prevention and control management, find high-risk account transactions in time and implement dynamic tracking to reduce the risks involved in related accounts.

Xue Hongyan said that banks should improve the recognition accuracy of the monitoring model; For the account that triggers the limit adjustment mechanism, more options should be given to remove the restrictions, especially allowing users to operate online, so as to reduce the time cost and transportation cost of counter application.

　　On February 22, Cheng Jiguang and his wife finally reunited with their son Cheng Xueping, who had been separated for more than 30 years. The family wept with joy. Image source: Huaxi Dushi Bao police for the picture

　　In early spring and February, in northern Sichuan, the atmosphere of the New Year has not yet dispersed, and rape blossoms have begun to spit yellow dew gold. On February 22nd, Qin Yujie, from Jize County, Handan City, Hebei Province, traveled thousands of miles with his wife and children and rushed back to his "home" in nanbu county, Sichuan Province.

　　At the age of 3, Qin Yujie was separated from his parents. In order to find him, my father traveled all over China with pickles on his back. In Handan, because he pronounced "shoes" as "children", he was called "Southern Baby" by the villagers. All along, he has been looking for his biological parents.

　　Finally, with the help of Sichuan police and Hebei police, the DNA comparison of father and son who have been separated for more than 30 years was successful. On February 22nd, the family finally reunited.

　　The hug that came 30 years late said "stop crying" but tears kept flowing.

　　On the 22nd, Qin Yujie finally returned to Chengjiawan Village, Xingsheng Township, nanbu county. One kilometer away, you can see the banner of "Welcome Baby Home", the sound of firecrackers, and the enthusiastic villagers came from Shili Baxiang to meet them. The whole mountain village is boiling, which is more lively and festive than New Year’s Eve.

　　After more than 30 years, the blood relationship has been cut off. On this day, Qin Yujie confirmed that his original name was Cheng Xueping. Parents and sons hugged each other tightly, crying with joy, constantly wiping tears for each other and comforting each other "stop crying".

　　Send the prepared banner and take a group photo with the police, volunteers, family members and neighbors … … Qin Yujie is very busy. In order to celebrate the return of wanderers and the reunion of their loved ones, the family has already prepared a reunion dinner, competing with each other to pick up food for each other. Although there are tears in their eyes, the smile at this time is so sweet.

　　Passion surges, tears mingle with joy, holding my son’s hand, touching and checking the marks left on his head when he was young, asking, talking, caring and attaching … … A pair of fiery eyes are wet, and I can’t wait to spit it out after decades … …

　　The youngest son disappeared in Guizhou, and his father searched half of China with pickles on his back.

　　It dates back to 30 years ago. Cheng Jiguang and Gao Lingzhen, who live in Chengjiawan Village, Xingsheng Township, nanbu county, Sichuan Province, are hardworking and simple, living an ordinary and happy life. In July 1985, their son was born and named Cheng Xueping. In order to raise it well, I also took a nickname "Wa Wazi". The birth of a son added a new hope to this small family.

　　Originally, Xiaoxueping was taken by her grandmother, but Cheng Jiguang and Gao Lingzhen were going to work in Guizhou, and they were reluctant to leave their son at home, so they took him to Guizhou. Who knows that after about 20 days in Guizhou, the child disappeared.

　　One day in July 1988, Cheng Xueping, who was only three years old, was playing on the construction site, but in the evening, when Cheng Jiguang and his wife were busy all day, they found that their son had disappeared and immediately looked around the construction site. At that time, Cheng Jiguang thought that his son might be playing nearby, and he might be able to find it later, but a few hours later, his son still disappeared. After that, Cheng Jiguang and his wife began to embark on a long road to find children.

　　In order to find their son, the couple not only spent their savings from working for many years, but also owed a lot of debts. Due to lack of money, Cheng Jiguang had to carry dry food and pickles, and searched all over the country for his missing son, and searched most of China. Later, Cheng Jiguang and his wife entered the DNA blood sample data into the national abduction DNA database.

　　Nanwaiwa in rural Hebei pronounced "shoes" as "children"

　　At an early age, Qin Yujie of a village in Jize County, Handan City, Hebei Province felt different from other children in the village. He always pronounces "shoes" in other people’s mouths as "children", so he is often laughed at, and others say that he is a baby from the south.

　　Gradually, Qin Yujie knew that he was not his father’s own, and that his father was just a foster uncle. The "foster uncle" was single when he adopted him, but later he got a wife and his own children, so he was ready to give him away.

　　Qin Yujie, who was ignorant and afraid, begged the "foster grandmother" not to give herself away again. The kind "foster grandmother" let the eldest son adopt Qin Yujie and become his adoptive father.

　　In the adoptive father’s home, Qin Yujie has never had a birthday for 30 years. He is bent on finding his biological parents and "home" and wants to know where he came to Hebei.

　　DNA screening breaks through the fog and finds the son who has been separated for 30 years.

　　God helps those who help themselves. In July 2018, nanbu county police received a notice from their superiors that the DNA blood samples of Cheng Jiguang and his wife were highly similar to those of a man named Qin Yujie in the blood bank. After learning the news, Wang Hao, the squadron leader in charge of abduction, immediately contacted Qin Yujie to learn about his basic situation. However, at that time, Qin Yujie was a DNA blood sample left when he was working in a foreign country, leaving no identity information and contact information, and had already left his place of work. This clue was interrupted. Nanbu county police did not give up, further strengthened investigation and contact, and finally found out Qin Yujie’s identity information.

　　In November 2018, in order to ensure accuracy, the abduction police contacted Cheng Jiguang and his wife for a second DNA blood sample collection while looking for Qin Yujie. At the beginning of this year, Sichuan police contacted the police in Jize County, Handan City, Hebei Province, and found Qin Yujie who was highly similar to the "target object" and collected DNA blood samples sent by Hebei police.

　　On February 15th this year, the DNA comparison finally got the result, and the physical evidence appraisal institute of Nanchong City Public Security Bureau issued an appraisal document. The appraisal result showed that Cheng Jiguang and Gao Lingzhen were Qin Yujie’s biological parents respectively.

　　On the same day, the policeman Wang Hao informed Cheng Jiguang and his wife of the results for the first time, and the couple immediately burst into tears of joy. Huaxi Dushi Bao-Cover News

　　Reporter Wu Liufeng

　　The picture is provided by the police

　　In the crazy process of multinational pharmaceutical companies in China, grey means frequently appear. The GlaxoSmithKline case is just the tip of the iceberg. What are the criteria for multinational pharmaceutical companies to choose executives in China? What kind of deep background do they have?

　　After four senior executives of GlaxoSmithKline were detained, AstraZeneca, Sanofi, Lilly and other giants were also investigated by relevant departments, and the bribery scandal of multinational pharmaceutical giants intensified.

　　Multinational pharmaceutical companies have been operating in China for 30 years. Facing the huge market in China, the development and expansion of multinational pharmaceutical companies in China is more like a long-planned war. From the initial joint venture, to merger and acquisition, sole proprietorship, setting up factories and R&D centers in China, even the executives in China have changed from foreigners to local elites.

　　From tourism to immigration, from interviews to papers, the "grey marketing techniques" of pharmaceutical companies have also exposed the tip of the iceberg.

　　How do multinational pharmaceutical companies operate in China, and what are the arrangements for the establishment of various functional departments? How can multinational pharmaceutical companies penetrate into China step by step by relying on their strong economic strength and powerful government lobbying ability? What is the background of executives of multinational pharmaceutical companies?

　　Department secrets

　　The outbreak of GSK’s China Wo case presented a roadmap for a foreign company to promote drugs by illegal means in China. Zhao Hongyan, director of the legal department, liang hong, vice president and general manager of enterprise operation, Huang Hong, general manager of business development enterprise operation, and Zhang Guowei, president and director of human resources department, who are known as "GSK China Troika", were investigated by the public security department. Why did GSK executives in China collectively fall?

　　The reporter found that there is a very clear division of labor among mainstream European and American pharmaceutical foreign companies. The medical management of multinational pharmaceutical companies in China has been covered with political color.

　　A deputy general manager of a domestic pharmaceutical company told reporters, "Every multinational pharmaceutical company has different ways to play. The national market layout of multinational pharmaceutical companies in China is basically where the government relations built by the enterprises themselves extend. Considering the operation and security of multinational pharmaceutical companies in China, one of the main tasks of government relations management is short-term arrangement, medium-term plan and long-term plan, and there is a special annual budget for the expansion and maintenance of government relations. "

　　"Simply relying on market operation is not enough to maintain the production and development of enterprises. For example, the bidding management of provinces, the selection of essential drugs, the addition of medical insurance catalogues, and the new GMP standards will all be controlled and influenced by relevant national policies. Therefore, on the first day of investment in China, multinational pharmaceutical companies in Europe and the United States regard influencing government-related decision-making departments as their most important task. " A staff member of a medical association told reporters.

　　Pharmaceutical enterprises build their own government relations network nationwide, on the one hand, relying on the government relations department of the company, on the other hand, giving full play to the personal connections and business capabilities of resident marketers, and on the other hand, relying on the commercial customers of pharmaceutical enterprises.

　　An industry insider who did not want to be named said, "Multinational pharmaceutical companies are even more aware of the layout of approval power before and after the reform than government officials, and their familiarity with policies, laws and regulations is much higher than that of domestic pharmaceutical companies."

　　There are 11 departments in China headquarters of GSK. The four departments involved in this case are Legal Affairs, Human Resources, Business Development and Enterprise Operation. What is the department setup and division of responsibilities of multinational pharmaceutical companies in China?

　　The Ministry of Government Affairs is mainly responsible for developing and carrying out related work with National Medical Products Administration, the National Development and Reform Commission, the Price Bureau, the industrial and commercial departments, the Ministry of Justice and other government functional departments, and establishing and maintaining good communication and contact with relevant units and departments. For example, be responsible for the company’s product declaration and selection in the national or local basic medical insurance drug list, and ensure that the company’s products are selected in the trade name list or synonym library in relevant regions; Responsible for the bidding and winning of the company’s products in relevant regions of the country, improve market access, and ensure that the company’s products have good channel environment and policy environment support.

　　The Ministry of Public Affairs is mainly responsible for the work in the media and public propaganda. Publicize the public through some influential media or propaganda tools, such as newspapers, magazines, radio and television, and shape public opinion, thus affecting the decision-making of government departments or legislatures. In addition, carry out social welfare projects advocated by the government to shape the positive image of enterprises. Some common problems are provided to the legislature or decision-making body as experts and scholars or as alliance groups through industry associations, industry media, academic groups, etc.

　　Medical registration department, mainly dealing with new drugs on the market and National Medical Products Administration. Get more guidance and help from the national level, improve the efficiency of pharmaceutical companies in research and development, registration and approval of new drugs, and obtain policy support for existing products.

　　Business development department, mainly dealing with local pharmaceutical wholesale companies and price departments. Provide accurate and continuous information, trends and related policy analysis for internal departments of the company; Drafting opinions and supporting materials to provide reference and necessary support for other internal departments to negotiate with the official; Ensure the stability of the price system of pharmaceutical products.

　　The legal department is mainly responsible for dealing with the legal troubles that the company may face. Based on the long-term research on the policy and market of pharmaceutical industry, it provides policy judgments for pharmaceutical companies in their business decisions. Because multinational pharmaceutical companies are familiar with the laws of China, they directly contact legislators or government officials with decision-making power through formal meetings or other means, such as cooperating with the government to present the company’s position and views on behalf of the company, provide relevant information and share practical experience, so as to influence the decision-making of the government or legislative departments.