This year’s 23rd tropical storm "Fete" weakened into a tropical depression at 9 o’clock this morning in Jian ‘ou City, Fujian Province. At 9 o’clock, its center was located at 26.8 degrees north latitude and 118.4 degrees east longitude, with a maximum wind force of 7 (16m/s) and a minimum pressure of 998 hectopascals.

　　It is estimated that "Fete" will move to the south-west direction at a speed of 15-20 kilometers per hour, and its intensity will continue to weaken.

　　Because the intensity of "Fete" is obviously weakened and the wind force near the center is very small, the Central Meteorological Observatory lifted the typhoon blue warning at 10 o’clock this morning, but its residual circulation will still cause heavy rainfall in Jiangsu, Anhui, Shanghai, Zhejiang, Jiangxi, Fujian and other places. Please continue to pay attention to the subsequent wind and rain impact caused by "Fete".

　　In addition, the No.24 strong typhoon "Danasi" has been strengthened into a super typhoon at 8 o’clock this morning. At 8 o’clock, its center is located on the northwest Pacific Ocean about 850 kilometers east of Taipei, Taiwan Province, China, which is 25.2 degrees north latitude and 130.2 degrees east longitude. The maximum wind force near the center is 16 (52 meters per second), the lowest pressure in the center is 935 hectopascals, and the radius of the 7-level wind circle is 350 kilometers.

　　It is estimated that Danas will move to the north-west direction at a speed of 25-30 kilometers per hour, and its intensity will be maintained or slightly strengthened. From this afternoon to night, "Danas" will move into the southeastern part of the East China Sea.

　　Affected by cold air, Feite and Danasi, there will be 7-9 winds in the southern part of the Yellow Sea, most of the East China Sea, the Yangtze River estuary, Hangzhou Bay, the coastal areas of Zhejiang and Shanghai from this afternoon to tomorrow noon, among which the winds in some sea areas are 10-12, and the winds in the nearby sea areas where Danasi Center passes can reach 13-16; There are heavy rains or rainstorms in central and southern Jiangsu, southern Anhui, Shanghai, Zhejiang, northeastern Jiangxi and northern Fujian. Among them, there are heavy rains (100-150 mm) in parts of northern and western Zhejiang, southeastern Anhui and northeastern Jiangxi.

(Source: Editor of Central Meteorological Observatory: Shi Long)

It is reported that Xiaomi has reached a strategic cooperation with the Central Radio and Television General Station and has become a strategic partner of CCTV’s "People, Cars, Home and Ecology", which is the first such cooperation in China.

In addition, Xiaomi was awarded the title of "CCTV Brand Power Project" by CCTV, becoming the second technology enterprise after Huawei.

Previously, CCTV News reported many times on Xiaomi’s scientific and technological innovations, including Xiaomi’s OS, the manned space launch of Shenzhou 16 and the construction of the first large domestic cruise ship.

Xiaomi 澎湃 OS is an operating system focusing on cross-end interconnection and artificial intelligence implantation, which is "the whole ecology of people, cars and homes". Its cross-layer "HyperConnec" breaks the barrier between devices and realizes unified connection protocol and real-time communication.

澎湃 OS also supports cross-end Zhilian, which enables devices to work seamlessly through dynamic real-time networking and integration of device centers. Xiaomi SU7 will be equipped with 澎湃 OS to realize seamless linkage between cars and mobile phones.

In addition, Xiaomi Mijia equipment can also get on the bus without feeling, realize seamless management and use on the big screen of the car, and create an intelligent travel experience of the Internet of Everything.

　　Biography of Naruto: New Endurance Attack is a brand-new attempt of Naruto IP, which is different from the extreme storm series that is good at telling stories and performing effects. Naruto: New Endurance Attack focuses on online PVP. In this game, online battle of 4V4 is the main gameplay. Players compete with other players in different modes by teaming up, thus improving their level and dominating Endurance League. The biggest selling point of this game is the powerful customization system. Players will no longer play the role in the original, but create a unique "ninja" by customizing ninja, equipment and image. This also allows it to distinguish itself from the extreme storm series.

　　However, this insurmountable "mountain" is undoubtedly a difficult challenge for "Huo Ying: New Endurance Attack". From the previous preview, the first impression of the game is very profound, and the customized system with strong plasticity in 4V4 online battle has successfully attracted the attention of the original fans. Then, can "Huo Ying: New Endurance Attack" carry forward this IP on the road of the game like the extreme storm series?

The scene between Naruto and Sasuke is as bad as the scene where Batman’s parents died.

　　The story of "Huo Ying: New Endurance Attack" happened after the comic book Endurance World War, when Naruto had become Huo Ying. In order to better prevent future wars, Konoha organized a Endurance World League with other villages. The player is a contestant and comes to Muye Village to participate in the competition. Different from playing the original role in other Huoying games, in Huoying: New Endurance Attack, with the powerful custom system of the game, players can pinch out unique roles. The advantage of not controlling the original role is that players can participate in the battle in their own capacity, giving players the greatest sense of participation.

　　If you read the original, you will find that although there are many options for each part, most of them actually split the characters’ faces and costumes in the comics for players to choose from. If you don’t like the original role, you can make an identical one according to the role you like.

From head to toe, clothes to accessories can be customized, and you will often see all kinds of strange and fancy players in the hall.

　　The custom system of the game is not limited to the shape of the character, but can be reflected in the "avatar system" of the game. You can understand this system as a profession. Players decide their own role attack methods according to four basic types. Of course, you can switch at any time in the subsequent battles.

　　Avatars are mainly divided into attack, defense, shooting and healing. In fact, you can put them in the right place with other basic occupations that are common in online games. Attack is good at melee output, shooting is good at remote output, and most skills of defense are defensive. The more you play an auxiliary role in the team, the more you are a wet nurse, which can support your teammates. Each battle consists of a team of four players. Although theoretically speaking, it is reasonable to output one T and one wet nurse according to the matching of occupations, in fact, in this game, attack and shooting have a great advantage in the battle, and teams like 4 attacks, 2 attacks and 2 shots often appear, while Shouheyue rarely sees them play because of their low attack power.

The skills of the characters are all familiar moves in the original, and they can be combined at will according to different occupations.

　　Each class has two main skills and an arcane meaning, and the weapons it can carry are also different according to different classes. It should be noted that the professional customization system is very powerful. As long as the players upgrade their level, the obtained ninja skills can be matched at will. You can either let the characters open eight armor-dodgers and put spiral pills, or you can use them together with Deidara’s explosives.

Players can worship the characters in comics as masters and learn their unique skills by upgrading their level.

　　Of course, the system also provides players with a number of characters in comics. If you are tired of using custom characters, it is also a pleasure to use a set character.

As a random game, there are only 20 characters in comics available to players at present.

　　It should be noted that playing needs to be connected to the internet all the time. It is not easy to play smoothly. Besides having a good network environment, the server is often disconnected and stuck, which has become a "threshold" that hinders players’ smooth experience. At the same time, each battle needs to be matched on the basis of a player’s network. If the owner’s network is not good, the other seven people in the room will be stuck and affect the battle, or they will be kicked out of the room to match again. This situation of being kicked out without rhyme or reason appears very often in the game.

This is probably the most common interface you see when you experience the game.

For more information, please pay attention to:

　　Some time ago, Lu Wei, a graduate of Beijing Institute of Technology, returned to her hometown and became a directional Selected Graduates in Guangxi Zhuang Autonomous Region. Talking about this choice, she said: "With the help of the national funding policy, I successfully completed my studies. I am duty-bound to return from my studies and build my hometown. "

　　Like Lu Wei, thanks to the increasingly sound student financial aid system, more and more students are no longer out of school because of family financial difficulties, but also get incentives for self-improvement and all-round development. The reporter learned from the Ministry of Education that at present, China’s student financial aid has realized the combination of multiple policies of "award, assistance, loan, exemption, diligence, supplement and reduction", with an annual subsidy of 160 million people and an annual subsidy of more than 290 billion yuan.

　　The system is more complete

　　All classes, all schools and all students with financial difficulties from families are fully covered.

　　Fu Huiping was born in a remote mountain village in Hongya County, Meishan City, Sichuan Province. In 2012, her father was accidentally injured at the construction site, resulting in lifelong disability, which made the poor family worse.

　　"Just when we were most embarrassed, the care of the party and the government came quietly." Fu Huiping said that during junior high school, on the basis of the "three exemptions" policy of compulsory education, she enjoyed an annual living allowance of 1,250 yuan for students from poor families and an annual education poverty relief fund of 2,000 yuan. During senior high school, I will enjoy 3,000 yuan of state grants and 1,500 yuan of educational poverty relief funds every year.

　　With the continuous support, Fu Huiping was able to study with peace of mind. Last year, she was admitted to Sun Yat-sen University with excellent results. At the same time, she received a subsidy of 5,000 yuan from 1000 yuan and Yucai Education Foundation for freshmen, and applied for a student loan.

　　"Along the way, I remember everyone who helped me and every student fund." Fu Huiping said: "I want to turn care into the driving force to move forward, study hard, and pass on love and hope."

　　To protect people’s livelihood and warm people’s hearts, student financial assistance is related to education equity and people’s livelihood well-being. In recent years, from the establishment and implementation of the pre-school education funding system, to the exemption of tuition and miscellaneous fees for students with financial difficulties in ordinary high schools, to the establishment of national scholarships for secondary vocational schools, and the introduction of national funding measures for college students to enlist in military service, the scope of student funding has gradually expanded and the scale has steadily increased, achieving three full coverage of the funding policy "all classes, all schools and all students with financial difficulties in families".

　　Not long ago, the Notice on Adjusting and Perfecting the Relevant Policies of Student Loans was issued, which clearly stated that the maximum loan amount per student per year of national student loans would be increased by 4,000 yuan, the interest rate of national student loans would be reduced by 30 basis points, and the commercial student loans for graduate students would be carried out at the same time. The relevant person in charge of the Ministry of Education said that with full consideration of China’s economic and social development and the changes in students’ needs for assistance, the funding policies for each school section will be gradually improved.

　　"China’s student financial aid policy system includes not only the policy of helping the poor, but also the policy of rewarding the excellent and encouraging and guiding. The introduction, adjustment and improvement of each financial aid policy have been fully investigated and demonstrated, which not only draws lessons from international common experience, but also considers China’s economic and social development, and strives to solve the urgent problems of the people, fully demonstrating the characteristics of China." Ding Xiaohao, a professor at Peking University Institute of Education, said.

　　Help is more accurate

　　Big data analysis has become a staff assistant for student financial assistance.

　　Li Yafeng, from Zhangbei County, Zhangjiakou City, Hebei Province, was both excited and anxious when he received the admission notice from Xi ‘an Jiaotong University: "There was a rainstorm and flood disaster this summer, and our family suffered serious economic losses. I don’t know if I can apply for a difficult subsidy in a situation like mine? "

　　When I was at a loss, the phone call from the school counselor solved the urgent needs of Li Yafeng’s family. "Before entering the school, the teacher gave me a detailed introduction to the funding policy, and guided me to apply for a special subsidy for disaster relief and apply for a student loan. At the time of registration, students will be admitted through freshmen ‘ Green channel ’ I entered school smoothly, and the school also distributed necessary daily necessities such as mattresses. " Li Yafeng said that these cares made him feel very warm.

　　In the process of student financial aid, how to ensure that no one is left behind, that no student is dropped out of school because of family financial difficulties, and how to put every penny into practice and play its role? "Accuracy" becomes the meaning of the title.

　　"Precision funding should be supported by informationization, so that data can become a staff assistant for student funding." Sun Zao, deputy secretary of the Party Committee of Xi ‘an Jiaotong University, introduced that the school has set up a big data analysis and service platform, comprehensively opened up the business systems of 16 departments, including academic work, teaching, enrollment and employment, and built a multi-dimensional and full-cycle growth file for students, so as to accurately depict students and accurately identify the aided students. For abnormal situations such as sudden changes in consumption habits, decline in academic performance, irregular attendance and rest, through early warning information, counselors and class teachers are reminded to follow up in time to carry out difficult subsidies, academic counseling, employment counseling, psychological assistance and other related work.

　　Accuracy is the inevitable requirement and the basic method of student financial aid. Henan province has fully implemented the national funding system, implemented the data periodic reporting system, realized the informationization of funding management, and also developed a facial recognition supervision system to promote the funding into the "one card" distribution of benefiting the people and farmers; Peking University opened the Yanyuan sailing project to help the funded students in a grid way, so as to realize the cross coverage of the financial aid managers and sailing instructors for students with financial difficulties; Zhongnan University of Economics and Law encourages faculty and staff to integrate home visits of poor students into work such as out-of-town investigation, exchange and discussion, social practice, etc., and strive to improve the accuracy of the identification of funded objects … … Schools around the country take measures to ensure that student financial assistance is fairer and more efficient.

　　"Starting from formulating the basis for identification, refining the working procedures, and establishing a comparison mechanism, we can accurately identify the aided students, find the accurate base, use technical means to carry out smart funding, and use big data analysis to carry out invisible funding. Nowadays, the accuracy and timeliness of the implementation of student financial assistance policies have been significantly enhanced." Ding Xiaohao said.

　　Cultivate more comprehensively

　　Attach importance to the improvement of students’ comprehensive quality and ability

　　Some time ago, Liu Liwen, a student of Beijing University of Posts and Telecommunications, participated in a theme social practice that impressed him deeply. During the 10 days, the team members came to Tibet, made an investigation in the border villages in Lajiao Township, Luozha County, carried out patriotic propaganda in rural primary schools, and patrolled the border with border guards and border guards … …

　　"I come from a remote township in Sichuan. As a beneficiary of the student financial aid policy, I have the opportunity to come to the frontier and witness the development, changes and prosperity of the motherland. I am very grateful to the country and the school, and I will work harder, be more tenacious and be more active in my future study and life." Liu Liwen said.

　　"It is one of the important goals of our student financial aid work to let students enter the society, go deep into the front line, understand the national conditions and people’s feelings, and cultivate the feelings of home and country." Alice Chan, director of the Financial Aid Center of Beijing University of Posts and Telecommunications, said that the school has gradually established an all-round and diversified financial aid and education system to ensure that every aided student has a secure life, motivation to learn and a platform for development.

　　In recent years, student financial aid has gradually extended from security to development, and the aided students have developed in an all-round way. Schools all over the country integrate socialist core values into scholarship selection, grant application, student loan handling, work-study and other links, carry out in-depth inspirational education, gratitude education and honesty education, focus on cultivating students’ spirit of striving for Excellence, glorious consciousness of labor and self-improvement quality, and guide students to establish a correct outlook on success, employment and values.

　　At the same time, under the guidance of the subsidy policy, "solving difficulties — Educating people — Become a talent — A virtuous circle of feedback has gradually taken shape. Hundreds of thousands of aided normal students have devoted themselves to rural basic education, which has improved the quality of rural teachers; A total of 750 thousand college graduates have taken root in the central and western regions, hard and remote areas and old industrial bases, optimizing the structure of grassroots cadres and professionals; A total of 1.76 million people have enjoyed state funding for military service (including direct recruitment of non-commissioned officers), which has promoted the modernization of national defense and the army.

　　"Student financial aid must adhere to the people-oriented principle. While doing a good job in economic assistance and life assistance, we should pay more attention to students’ quality training and ability improvement, give more support and help in study and study, provide and create more opportunities in social practice, and provide more guidance and help in employment and entrepreneurship." The relevant person in charge of the Ministry of Education said that it should be a higher pursuit of student financial assistance to make every child grow into a talent and realize his life dream.

　　(Zeng Yuxi participated in the writing)

　　For human beings, love is an endless topic. What is love? Everyone may have different opinions, but there is no denying that true love is a power to make people better.

　　Speaking of cars, people subconsciously think of cold steel and hard-core industries. Euler, a new energy car that loves women more, is committed to being a romantic alien in this industrial world and deeply rooted "love" in the brand gene.

　　On August 20th, Euler Auto "Better for Love", together with many online and offline users, witnessed the launch of the 400,000th complete car of Euler, and the latest achievement created by the brand and users, the 2023 Good Cat & Good Cat GT Mulan Edition, was also listed at the same time, with a limited cash benefit of 129,800! On the same day, it coincided with the fifth anniversary of Euler’s founding. Euler, who grew up with users, not only invited users to visit the park, punch cards and interact, but also linked online users with 8 hours of live broadcast activities to witness the important moment of the brand and share a feast of love.

　　400,000 love, condensed in a moment: Euler’s 400,000 th car rolled off the assembly line.

　　Euler has always regarded users as the first driving force for brand growth. Brands talk to global users with love as the world language, and carry forward the power of "more love" with practical actions.

　　Because of "more love", it is loved, and Euler Auto has gained the love of more and more users. In this activity, Euler welcomed the 400,000 th vehicle off the assembly line, and connected directly to Great Wall Motor Taizhou Smart Factory to witness this special Euler good cat driving out of the factory with users. Taizhou factory is the eighth largest vehicle production base built by Great Wall Motor in China and the strategic core of East China market, and is regarded as the "intelligent new engine" of Great Wall Motor’s new energy strategy. Relying on such a high-standard production system layout, Euler continues to provide users with high-quality and high-value automobile products. The automobile products under the brand have fully covered the A0-class to B-class market, which not only created a new category of women’s automobiles, but also gave them a new definition from a new perspective, creating more big items with a better life for women to travel.

　　Perhaps, the weight of love can’t be calculated by numbers, but Euler walks with 400,000 gentle forces with sincerity. In order to break the prejudice of cars against female consumers, Euler broke away from convention and became the first car brand in the world to clearly support women, focusing on the women’s car track. To this end, the Euler brand redefined the women’s track with technology and created the world’s first 1080 women’s safety architecture — — Warm technology makes "female car" not only a marketing amulet, but also a technical moat.

　　Because of love, Euler saw the bloom of "genius mother"; Because of love, Euler joined hands with women to run the marathon of life; Because of love, Euler is willing to bend over to be the stage … … Euler firmly stands with women and works with users to build a feminine charm culture, witnessing the vitality, elegance, courage and exquisiteness of contemporary women, so that every bloom has strength. In Euler’s user base, the repurchase rate exceeds 26%, the referral rate exceeds 31%, and the proportion of female users exceeds 75%. The brand is deeply recognized and affirmed by the majority of users. At the same time, today’s Euler has already gone abroad, heading for 87 countries and regions around the world, talking to users around the world with love as the world language, and letting the world see the power of tenderness.

　　As the leader of the new track for women’s cars, Euler has no fear of becoming a "lone warrior" in the industry. The brand was born in wonder, but also grew up in doubt and created new miracles, which made people see that in the world of cars, there are not only hardcore, parameters and competition, but also tenderness, delicacy and love. The 400,000th vehicle rolled off the assembly line, which means that the Euler brand will soon have 40 copies of support from users. There are 8 billion people in the world, and 400,000 of the 8 billion people may be small, but it is the love from users that makes the Euler brand more emboldened and more confident.

　　For the sake of love, the 2023 Good Cat & Good Cat GT Mulan Edition was launched with a limited time cash benefit of 20,000 yuan.

　　As early as this year’s Shanghai Auto Show, the Euler brand started the recruitment of "Good Cat Co-creation Officer" and received many valuable suggestions from users in the past four months. The newly listed 2023 Euler Good Cat and Euler Good Cat GT Mulan Edition are the latest achievements created by Euler and users, and they are also the witness of Euler’s love with users.

　　Relying on the forest ecological R&D system of Great Wall Motor, Good Cat and Good Cat GT are equipped with the high-performance permanent magnet synchronous motor developed by Great Wall Motor, which is stronger, faster and quieter. While continuing the high quality of "Three Good" cats, the performance of the new car has been improved in an all-round way. It can achieve the maximum power of 135kW and the peak torque of 232N·m, and the acceleration of 0-50km/h takes only 3.5s, which is faster, more energetic and more powerful in the middle section, making it easier for both high-speed driving and urban commuting. At the same time, its maximum climbing degree is increased by 9% to 38%, and it can be more comfortable to go uphill and downhill, so it is possible to travel more when unlocking. Combined with user feedback, the new car has achieved better NVH performance, and can have better quietness when sitting in the car, bringing users a more comfortable and pleasant driving experience.

　　In addition, Euler brand pays attention to young people’s love for exquisite camping. Both Good Cat and Good Cat GT are equipped with V2L external discharge function, and the discharge power can reach 3.3 kW. In the wild, it is easy to use coffee machines, induction cookers, even projectors and other plug-in devices to easily meet the electricity demand of a family camping. Imagine that you can sit around with friends and family under the stars, watch a movie, enjoy a concert, or pick up a long-lost electric guitar and "roar" with your companions, from the city to the countryside, from high-rise buildings to castle peak, just by 2 hours’ drive.

　　In order to better give back to users, Euler brand has launched a cash discount of 20,000 yuan and free installation of charging piles for Good Cat and Good Cat GT! The 2023 Euler Good Cat 401km honorable model, the national suggested retail price is 149,800 yuan, and the price is 129,800 yuan after limited time; The 2023 Euler Good Cat 501km honorable model, the national suggested retail price is 165,800 yuan, and the price is 145,800 yuan after limited time; The 2023 Euler Good Cat GT Mulan Edition is a 401km honorable model, with a suggested retail price of 153,800 yuan nationwide and a price of 133,800 yuan after limited time. At the same time, the subscription users of Good Cat Honor can enjoy the external discharge function of V2L worth 2999 yuan for free; The good cat GT with V2L function has come standard, and you can also choose the intelligent assisted driving optional package at a 50% discount price!

　　Users are always Euler’s precious wealth and the source of power to support Euler’s continuous progress. Insisting on joining hands with users and "creating for love" also makes Euler’s products better and better. Better understanding of the user’s product strength upgrade, more people-friendly prices, and greater concessions are the most authentic feedback from Euler to users.

　　From the past to the present, from 0 to 400,000, Euler has been practicing the promise of "more love" with practical actions. Euler brand regards love as a long-term cause and sincerely pays tribute to trust. In the future, Euler will also continue to walk with users, work hard for dreams and career together, and work with thousands of "her" in Qian Qian to love and be better. (Photo: Provided by Great Wall Euler)

　　Red Net News April 28th(Reporter Wang Heng He Qing Photography Li Changhong Xu Shijie Li Saifeng) The new era calls for new actions and a new journey to write a new chapter. In order to welcome the 20th Party Congress, on the morning of April 28th, the 2022 "Praise China" online comment contest with the theme of "New Era, New Journey and New Youth" was officially launched in Changsha, Hunan Province, and entries were collected for the whole country.

　　The event was jointly sponsored by the Network Communication Bureau of the Central Network Information Office, the Network Social Work Bureau of the Central Network Information Office, the Ideological and Political Work Department of the Ministry of Education, and the Propaganda Department of the Communist Youth League Central Committee. It was hosted by the Network Information Office of Hunan Provincial Party Committee and implemented by Hunan Hongwang New Media Group. The purpose of the activity is to further promote the high-quality development of online comments, vigorously carry forward the main theme of the times, spread the positive energy of the network, lead the majority of netizens to share the same fate with the motherland, and further unite the majestic power of unity and forge ahead, so as to create a good online public opinion atmosphere for the party’s twentieth victory.

　　Yang Haodong, member of the Standing Committee of Hunan Provincial Party Committee and Minister of Propaganda Department of Hunan Provincial Party Committee, announced the official launch of the contest.

　　According to the organizer of the contest, online comments are an important part of Internet content construction, which is related to the clear cyberspace. It is necessary to strengthen ideological guidance and guide the public opinion to the ballast stone; Focus on rallying people’s hearts and draw concentric circles of struggle and forge ahead; Sharpen patriotic feelings and sublimate the new "sound" state of patriotic expression; Adhere to integrity and innovation, and create a new hotspot for creative expression. It is necessary to inspire and guide young people with great achievements in the new era, and give play to the communication advantages of new media to attract and unite young people. It is expected that netizens will actively participate in the contest, eulogize the times and cheer for the people.

　　The contest welcomes the participation of the vast number of online commentators, especially young authors, and looks forward to launching a large number of masterpieces and discovering and cultivating more outstanding online commentators.

　　The collection scope of the contest works includes online commentary works that meet the requirements of the contest collection and have not been publicly released, and online commentary works that have been publicly released on various websites and platforms in China from August 1, 2021 to June 30, 2022. Individuals can participate in the competition independently, or they can be recommended by party and government organs, enterprises and institutions, media websites and social organizations. After the collection of works, expert judges will be organized to carry out multiple rounds of evaluation, and 100 outstanding works, 300 finalists and 30 outstanding organizational units will be selected from the entries.

　　At the launching ceremony, responsible comrades of the Network Communication Bureau of the Central Network Information Office, the Department of Ideological and Political Work of the Ministry of Education, and representatives of relevant experts and commentators delivered speeches by video. Responsible comrades of relevant departments in Hunan Province and representatives from the media attended the launching ceremony.

　　According to the activity arrangement, April 28th to June 30th, 2022 is the time for collecting works, and the contestants and units can submit their works through official channels such as official website (https://hpzg.rednet.cn).

　　[News link]

　　New era, new journey, new youth

　　2022 "Praise China" Online Comment Contest Solicitation Announcement

　　In order to effectively promote the high-quality development of online reviews, vigorously carry forward the main theme of the times, spread the positive energy of the network, and more unite the majestic power of forging ahead, the 2022 "Praise China" online review contest was officially launched, and now the entries are collected for the whole country.

　　I. Theme of the event

　　New era, new journey, new youth

　　Second, the organization

　　Organizers: Network Communication Bureau of the Central Network Information Office, Network Social Work Bureau of the Central Network Information Office, Ideological and Political Work Department of the Ministry of Education, and Propaganda Department of the Communist Youth League Central Committee.

　　Organizer: Network Information Office of Hunan Provincial Party Committee

　　Executive unit: Hunan Hongwang New Media Group

　　Third, the direction of collection

　　Guided by the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, around the historic achievements and changes in the development of the party and the country in the new era, combined with the reform and innovation practices in various industries and fields in various places and the great changes in people’s production and life, we face up to concerns and make rational comments, and deeply explain the great advantages of the party’s leadership and the Socialism with Chinese characteristics system through empathetic perspectives, profound and unique thinking and warm strokes. Vividly interpret the theoretical logic and practical logic behind extraordinary achievements and happy life, and vividly present the surging weather of the motherland’s galloping development and the prosperous times of Chinese children.

　　Fourth, the collection time

　　April 28th to June 30th, 2022.

　　V. Scope of solicitation

　　1. Publicly released works: online review works that were publicly released on various websites and platforms in China from August 1, 2021 to June 30, 2022 and met the requirements of the contest collection.

　　2. Unpublished works: online commentary works that meet the requirements of the contest and have not been publicly released.

　　Sixth, the collection method

　　The declared works include three categories: text comments, video comments and comic comments, which were collected online through the contest in official website (https://hpzg.rednet.cn).

　　1. Self-declaration: individuals can declare and upload their own works through online collection channels, and the number of works in the same category should not exceed 3.

　　2. Organization declaration: Party and government organs, enterprises and institutions, media websites, social organizations, etc. can declare and upload works by organizing recommendation through online collection channels, and each unit recommends no more than 20 works. When submitting, you need to attach a scanned copy of the organization recommendation letter stamped with the official seal of the unit.

　　VII. Solicitation requirements

　　1. Correct orientation, profound conception, clear viewpoint, rigorous logic, fluent expression and seeking truth from facts;

　　2. Innovative discourse forms and presentation forms, which are suitable for network communication and have strong appeal and communication power;

　　3. For literary works, it is required that the long review articles should not exceed 3,000 words and the short review articles should not exceed 1,200 words; Video works require ordinary video to be within 8 minutes, short video to be within 3 minutes, and the format is MP4 and MOV, not exceeding 800 m; Random review works require cartoons to express opinions, pictures with short text explanations, etc., in JPG； format;

　　4. All works must be copyright-free, and the contestants agree to authorize the organizers of the competition to use the rights of reproduction, information network dissemination, adaptation and assembly of the entries.

　　Eight, award setting

　　1. 100 outstanding works (including about 60 works of words, 30 works of videos and 10 works of random comments);

　　2. 300 short-listed works (including 180 works of words, 90 works of videos and 30 works of random reviews);

　　3. 30 outstanding organizational units.

　　IX. Activity Flow

　　1. Start the solicitation. The 2022 "Praise China" online comment contest was launched in the whole network, and the channels for submitting works were opened for online collection.

　　2. Qualification review. Take a combination of technology and labor to remove works that do not meet the requirements of applying for qualification, and form a preliminary evaluation list.

　　3. Preliminary evaluation. According to the evaluation rules, the Preliminary Evaluation Committee selected 1000 works to form a re-evaluation list.

　　4. Re-evaluation. The Re-evaluation Committee selected 300 works according to the evaluation rules, and after verifying the authenticity of the declared information, a final evaluation list and a shortlist of works were formed.

　　5. Final evaluation. The final evaluation committee selected 100 outstanding works and 30 outstanding organizational units according to the evaluation rules, and publicized them through the contest in official website.

　　6. Release the results. Hold the release ceremony of the results of the 2022 "Praise China" online comment contest.

　　The right to interpret the activities of this contest belongs to the organizer.

　　The brand positioning is scene intelligent electric vehicle. Before the car was experienced, this positioning was relatively conceptual. However, after the test drive of this iCAR 03, I really realized the technical cohesion of this "science man" for the ultimate scene, which is not limited to the elevation of the black technology software of the car, but also can put the high-level off-road ability that A-class pure electric city SUVs dare not play into iCAR03. I really didn’t expect that the seemingly "harmless" iCAR03 is not just as simple as a household electric car, but also has great achievements in the all-terrain field, such as easily climbing the 38-degree high slope, easily climbing the stairs, easily passing through the cross shaft, easily passing through the water pool mixed with ice fragments, etc., making cross-country very easy, which completely subverts people’s cognition of iCAR brand and always thinks that it is just a scooter.

　　After the off-road venue, I really feel that the brand’s promotion to iCAR03 is too conservative, and it is not as simple as "electric tidal box SUV".

　　Simple appearance but not simple

　　Last year was the year when China brand launched more square box-type off-road vehicles. Although iCAR 03 is also a square box shape, it is difficult for you to directly associate it with off-road vehicles and hardliners. However, if you look closely, there will be a ""content in the profile of the side body. However, in addition, the appearance of iCAR 03 is more original lines.

　　ICAR 03′ s external dimensions are 4406mm long, 1910mm wide, 1715mm high, and the wheelbase reaches 2715 mm. The overall shape is very square, and the tough body contour is outlined by using very geometric lines, which is friendly to the interior space.

　　The shapes of the light groups at the front and rear of the car are consistent, and they all use the shape of the "I" digital intelligent light group. The shapes of the front and rear light groups echo each other, and also echo the iCAR logo. The front lights have six kinds of intelligent lights, and the overall shape is relatively simple, but it has a high recognition rate. However, this kind of thing is definitely different for individuals.

　　The shape of the square box is simple, but the details are not simple. In addition to the small intention of the light group, iCAR03 uses an electric hidden door handle, which has an ice-breaking power of 120N in the snowy winter.

　　The appearance details are also reflected in the four-wheel eyebrow lights, all of which are embedded with "I-mark lights". This design is rare in other models. It can be said that the iCAR brand is very careful in increasing vehicle recognition.

　　In addition, there are two details: the design of iCAR at no cost. One is that the rear tailgate is opened at a 90-degree right angle only by hard-core off-road vehicles, in order to take things more conveniently. On this side tailgate, there is also an electric suction door, which can be automatically sucked with a slight clearance, so as to achieve the same configuration as the mainstream off-road vehicle, which not only saves worry and effort, but also from this aspect, the positioning of this model has slowly leapfrogged.

　　In addition to the tail door full of off-road flavor, a real small schoolbag was designed at the tail. In the past, off-road vehicles were called "small schoolbags" when they took a spare tire, but iCAR03 really installed a small schoolbag with Chaochuang personality, which can realize the wet and dry separation of take-away items. Press the point I in iCAR to open it, which is really intimate.

　　In terms of details, not only these, iCAR0 3 also has 50KG load-bearing luggage rack, 220V3.3kw external discharge, 1.6T traction qualification and 12V power supply in trunk. ICAR 03 adds a series of hardware for off-road, home and tide play, so that users can travel/drive with ease.

　　Interior Configuration of Intelligent Equal Rights

　　We see that the simple but not simple appearance is amazing, and the interior, configuration and intelligence are even more simple. The interior style of iCAR 03 has two colors: dark and light. It is expected that most users will choose the light interior because it is elegant, and the patchwork and rough outline make the interior style unique in the compact pure electric SUV.

　　The center console is equipped with two screens, a clear digital instrument screen and a 15.6-inch ultra-wide field of view central control large screen. The two screens have a clear division of labor, and for an A-class pure electric SUV, it can fully meet the demand.

　　ICAR 03 comes standard with Tencent Ecology, which meets the requirements of multi-instruction parallelism such as driving directions and entertainment. It has four-tone language control recognition, which can accurately identify the instructions issued by passengers from different locations, and the control is more intelligent and accurate. As well as full-scene voice control, greatly liberating multi-command control with both hands.

　　It can also expand mainstream APP applications, and its menu catalogue and function card design are easy to understand, and the pull-down shortcut function and air conditioning control are very intuitive.

　　It is worth mentioning that the intelligent cockpit of the four-wheel drive model adopts the 8155 chip, which can support the smooth playback of 8 channels of 4K video, and the 360 image and voice interaction function is supported by the 8155 chip to achieve the first-class in the same class. ICAR 03 also supports more than 20 intelligent modes such as pet mode, nap mode, karaoke mode and child lock mode.

　　In terms of audio and video configuration, this model is also the "top" configuration in the same level. The Infinity Swallow Lishi audio system equipped with 12 high-performance speakers above the four-wheel drive long-life advanced version has been professionally tuned by Harman Kardon.

　　In terms of technology configuration, it can be said that everything this handlebar can give is in place. For a model of 120,000-180,000 yuan, its configuration is rich and reasonable. In this respect, I have to admire Chery’s pursuit of cost control and technology.

　　Efficient power and reasonable configuration.

　　The power part of iCAR 03 is relatively mainstream, but in the mainstream, there is unexpected potential to be stimulated. The model of this test drive is a four-wheel drive version, equipped with dual-motor power, with a peak power of 205Kw, a wheel torque of 4100N·m, and an acceleration of 6.5s per 100 kilometers. The electric drive is a six-in-one flat-wire motor with the highest efficiency of 96.96%, which has the characteristics of high energy, high efficiency and low consumption.

　　As for the power battery, Contemporary Amperex Technology Co., Limited’s customized battery core is adopted, which has the characteristics of high energy density. In terms of battery cell energy density, the two-drive version is 401: 180.9 Wh/kg; Two-wheel drive 501 version is 182.19Wh/kg；; The version of the four-wheel drive 501 is 182.19Wh/kg, and the energy density of the 501 battery life package reaches 139wh/kg.

　　For battery protection, iCAR 03 adopts a "sandwich" structure with a 10mm battery protection armor body. The upper and lower versions of the battery pack are made of aviation grade material, the upper case is covered with 1000°C ultra-high temperature resistant mica material, and the lower case is made of aluminum alloy plate, which can achieve a pressure of 20kPa.

　　ICAR 03 has inherited Chery’s profound technical innovation ability in the aspect of three power plants, and has a long-term vision from capability to safety to sustainable use. For example, in terms of body structure and chassis, in order to enhance strength and reduce unsprung weight, iCAR has created a hybrid super-strong chassis, using a 3,500-ton integrated die-casting tower top structure and an all-aluminum honeycomb structure girder to form a super-rigid foundation. Hollow cast aluminum H-arm is adopted in the chassis structure of H-arm multi-link and hydraulic bushing, which reduces the weight by 30% and the unsprung impact.

　　In terms of body frame, it’s really worth saying more, because its body-in-white weighs only 230kg, which is not as heavy as an adult pig. In addition, the original all-aluminum multi-cavity cage body makes the curb weight of iCAR03 only start from 1.68 tons, which is a pure electric vehicle, and this innovation has laid a deep foundation for off-road ability.

　　Comfortable city driving

　　ICAR 03 with square box shape has advantages for riding experience, with ample head space and leg space brought by 2715 wheelbase, which is enough for a family of three to travel. The effective space utilization ratio of iCAR 03 vehicle reached 66%, and the interior space reached 64.3%.

　　The car has a super-large rear head space of the same level. According to official data, the rear head space reaches 991mm, which makes passengers’ activities in the car not cramped.

　　In terms of storage space, the whole vehicle has several extensible storage spaces, including the storage bin under the 24L rear seat and the backup storage space, which can be extended to 1238L.

　　In normal pavement driving, the acceleration of iCAR 03 is very rapid, and the required driving mode can be selected through the driving mode on Nakajima. iCAR 03 has 8+x all-road driving modes to choose from, and there are four modes to choose from on paved roads: energy saving/comfort/sports/personalization. If it is a four-wheel drive vehicle, the four-wheel drive and two-wheel drive will automatically switch during normal driving, which will bring more energy-saving performance.

　　For the iWD intelligent electronic control four-wheel drive equipped with iCAR 03, the performance on the pavement is very smart, and it will remain in the two-wheel drive mode most of the time, and will switch to the four-wheel drive only at the moment of starting and accelerating, and once the vehicle maintains a stable power output, it will remain in the two-wheel drive output.

　　ICAR 03 adopts the design of arms, which is very convenient when switching gears, moving forward and backward. When turning left and right, the central control screen will open the camera on the steering side to make up the blind spot, thus achieving a safer purpose.

　　Because the weight of the car body is the same as that of a fuel car, the starting and acceleration of iCAR 03 is very easy. Although it is also an electric car that has a smooth sense of acceleration, it is obvious that the support of the chassis is very resilient, and when turning at high speed, the control of the car body is very dexterous, and there is almost no inertia brought by the dynamic potential energy. The direction of the steering wheel is completely unified with the direction of the car body.

　　For the transmission of road conditions, iCAR 03 can transmit the road conditions as delicately as golf, especially the feeling between roads, potholes and gravel roads is relatively clear, the suspension is well supported, the resilience of shock absorption is obviously very tough, and there is room for accepting greater impact.

　　Generally speaking, the adjustment of iCAR 03 on paved roads is conservative, and it is mainly for the comfort of family cars, but it is not very radical. On the one hand, it shows that iCAR03 is positioned as a home and trendy car, not a performance car. However, the performance is not reflected in the pavement, but it is completely released in the off-road field.

　　Many cross-country events are not to mention.

　　Who would have thought that although the appearance of iCAR 03 has the value of "harmless to people and animals", playing in off-road venues, I think many hard-core off-road vehicles that sell more than 300,000 will not underestimate it. This off-road test drive was carried out on a site with a slope of 38 degrees. Seeing the models that don’t take off-road as the selling point, it’s really a sweat to challenge many hard-core off-road test sections, or I don’t have much confidence in iCAR 03.

　　However, the display is very cruel. iCAR 03 completely hit the face, not only with a 38-degree slope, but also with a cross shaft and a wading pool. Even the wheels will not slip, just adjust the corresponding driving mode in the car.

　　ICAR 03 can be regarded as a real software-defined car. Some SUVs that also use dual motors are just competing for acceleration time, but iCAR 03 makes it too easy for hard-core off-road to complete. When climbing a hill, you only need to stabilize the speed and look at the transparent body and direction displayed on the hollow screen, even without adjusting to any off-road mode.

　　After reaching the top of the slope, adjust the mode to flexible downhill, release the switch and brake, and the vehicle will firmly grab the ground and descend to the ground very stably, which makes the novice cross-country very calm. The difference between flexible downhill and steep slope descent is that the software is used to calculate the adhesion of each wheel, the slope data and the vehicle speed, and the torque release of each wheel is controlled more subtly, and the vehicle speed is controlled by a motor, instead of controlling the downhill vehicle speed to a set value in general.

　　With the difficult uphill as the foundation, it is actually easier to pass when facing the challenges of climbing stairs, small humps and narrow bridges.

　　What I didn’t expect was that iCAR 03 passed easily when it challenged the 30cm cross axle. We can see that when it crossed the axle, sometimes a wheel would be suspended and have no adhesion. At this time, IWD’s intelligent electronically controlled four-wheel drive can distribute the dynamic torque of the front and rear motors, start the wheel with millisecond-level response, and instantly increase the torque of the wheel with adhesion, so as to achieve normal passing. This does not require particularly high driving skills, just need.

　　What is even more surprising is that when many friends recommend various in-situ U-turn functions in a high-profile manner, iCAR 03 also has the ability of extreme turning, that is, after the steering wheel hits a certain side, the rear wheel will lock with the direction, forming a compass leg mode, dragging the vehicle to extreme turning, thus reducing the turning radius. In order to achieve this turning mode, you only need to select the extreme turning mode in the screen.

　　To sum up, the off-road capability of iCAR 03 is an unexpected bright spot, so that it masks its trendy nature. As the first model of iCAR brand, iCAR03 can definitely be called a pure electric compact SUV with a new height of "involution". If you are a cross-country enthusiast and just want to have a drink in the surrounding cross-country, iCAR 03 is a very good choice, and its price is still within 190,000, which is great for the cost of playing cars. If you are a user who likes go on road trip and needs daily transportation, the intelligence, comfort, space and expansion ability of iCAR 03 can fully meet your play needs, and it is a good choice for low-cost cars. Therefore, if you are interested in iCAR 03, you might as well go to its experience store to have a look.

The richness of a car configuration is related to the user’s car experience, so many people are concerned about its configuration today. Not much to say, let’s take a look.

First of all, from the appearance, the front face of Model Y has improved the grade of the whole vehicle and looks very sporty. Coupled with the sharp headlights, the grade of the whole vehicle has been improved. The car is equipped with LED daytime running lights, front fog lights, automatic opening and closing, adaptive far and near light, delayed closing and so on. Come to the side of the car, the car body size is 4750MM*1921MM*1624MM, the car uses sharp lines, giving people a very tough feeling, with large-sized thick-walled tires, giving people a very capable feeling. In terms of the rear end, the overall shape of the rear end echoes the front face, and the taillights give people a very tough feeling, and the shape is avant-garde.

Coming into the Model Y car, the interior of Model Y adopts a simple and generous shape, which highlights the layered effect. The steering wheel of the car is well designed and made of genuine leather, which gives people an impulse to control it. Let’s take a look at the central control, with a 15-inch touch-sensitive LCD central control screen, which makes the interior design quite layered, and the overall design of the central control is remarkable. The dashboard and seats are also eye-catching. The dashboard of this car presents a tough design style and looks very unique. The car adopts leather-like seats, which are wide and thick, improving the riding experience of drivers and passengers.

The Model Y is 357KW, the total torque is 659N.m, and the maximum speed is 250 km/h.

The space performance of the Model Y trunk is OK. If there are large items during the trip, you can put down the rear seats to expand the space. At the same time, the car is equipped with anti-lock braking (ABS), LED daytime running lights, brake assist (EBA/BAS, etc.), braking force distribution (EBD), traction control (ASR/TCS, etc.), main driving airbag, co-pilot airbag, side airbag curtain, front side airbag and other safety configurations.

Do you have the urge to buy a car after reading the whole article? Let me make a summary. This car has been introduced almost before, and I believe many users who buy a car have taken a fancy to its comfort and practicality.

This article comes from WeChat WeChat official account:CC weekly (id: cancer-weekly), Author: Zhang Yujiao (tenured professor of The University of Texas MD Anderson Cancer Center), original title: "Exclusive | These five groups of people cannot be vaccinated! Chinese scholars analyze the top ten problems of Pfizer vaccine, with the title from vision china.

Core summary

1. On the 10th local time, the US Food and Drug Administration（FDA）With 17 votes in favor, 4 votes against and 1 abstention, COVID-19 Vaccine Group decided thatThe benefits of using Pfizer /BioNTech COVID-19 vaccine in adults aged 16 and over outweigh the known risks, and the COVID-19 Vaccine Team of FDA recommended that Pfizer’s COVID-19 vaccine be approved.This means that the last obstacle has been cleared before the COVID-19 vaccine goes on the market in the United States.

2. The vaccination effect of tumor patients receiving chemotherapy and radiotherapy and patients undergoing bone marrow and organ transplantation needs to be studied. People who have been infected should also be vaccinated, but it is not recommended for pregnant women to be vaccinated. Patients with a history of severe allergies should also be carefully vaccinated.

3. At present, it can only be concluded that COVID-19 vaccine is valid for more than half a year.As for how long, we have to wait for the data to speak. According to the current state(Including the titer and maintenance of antibodies in early studies)It may be a year or so, I hope it will be longer.

4. The extent to which COVID-19 vaccine can reduce the chance of spreading virus after vaccination needs further study. Therefore,After vaccination, you need to wash your hands, wear a mask and be socially isolated.

On December 8th, the world’s first Pfizer COVID-19 mRNA vaccine was inoculated in the UK after the third phase clinical study confirmed its effectiveness. The 90-year-old lady told the media at the vaccination site with a strong British accent: "This is the best thing that has happened to me, both effective and free!" . The second vaccinator is an 80-year-old man. His name is William Shakespeare, and he has the same name as the great British writer.

On the same day, after three weeks of investigation, FDA issued a review statement: Pfizer vaccine has no safety concerns, and the effective rate can reach 52% after the first vaccination, and the effective rate will rise to 95% after the second vaccination, and the vaccine can significantly reduce the number of critically ill patients. FDA(US Food and Drug Administration)Decided to submit it to the expert Committee on vaccine efficiency and safety outside the FDA for public hearing, and the whole hearing will be broadcast live on national television.

By 30 FDA independent committees on vaccine efficiency and safety(composed of vaccine experts, doctors and representatives of the public)The hearing will be held from 9: 00 am to 5: 45 pm on December 10, US Eastern Time and December 11, Beijing Time.(Tubing, live broadcast by Twitter). Members of the Committee reviewed tens of thousands of pages of information in advance. After a heated debate, 17 votes in favor and 4 votes against the emergency use of Pfizer mRNA COVID-19 vaccine for adults over 16 years old.

At the hearing, Pfizer released detailed data for the first time. People over 16 years old, including those over 55 years old, have chronic diseases.(including heart and lung disease, cancer history)Those who have a history of HIV, HBV infection but have been controlled are all enrolled in the third phase of the study.

About side effectsMild to moderate discomfort at the inoculation site is very common. Moderate systemic reaction is about 18%, and serious side effects are less than 5%. The research is still going on, and the FDA requires Pfizer to submit updated information to the FDA in January until two years later.

About efficiency95% of the total protection efficiency occurred 7 days after the second inoculation. The protection efficiency of people of all ages and races is above 93%. It has a good protective effect on the history of basic diseases, including cancer.

At the hearing, the safety hazards such as patients with obvious immune deficiency, patients with severe allergic reactions, pregnant women and children were discussed. At the same time, the possibility of transforming mRNA into DNA and reducing the possibility of human-to-human transmission are discussed, and suggestions for future research are put forward, including further research on asymptomatic infected people.

The most controversial issue is whether teenagers aged 16 and 17 can be vaccinated, because there are only more than 100 people in this group in the study.. Some members are opposed to vaccinating teenagers aged 16-17, which is the main reason for voting against it. However, the FDA insists that because many 16-and 17-year-old children in the United States have started working in supermarkets, it is more dangerous.

On December 17th, another mRNA vaccine(Moderna Modena)An FDA hearing will also be held and approval is expected.

After nearly a year of long suffering, people finally saw the dawn. The British media said that "we are vaccinated with hope". However, in the face of more than 1.5 million lives lost around the world, we can’t help but sigh "too late". However, it is worrying that more than 37% of the American people are not willing to be vaccinated at present. They questioned"So soon? Is it safe? ！”

Take the United States as an example. Up to now, more than 15 million people in the United States have been infected with COVID-19, and nearly 300,000 people have lost their lives. The second wave of epidemic has just broken out in autumn and winter. Recently, there are 200,000 new cases and more than 2,500 deaths in the United States, far exceeding the first wave in July this year! At this exponential growth rate, if there is no vaccine and effective social isolation, the probability of each American being infected in 2021 will exceed 50%! Each of us should ask ourselves, should we be vaccinated, infected naturally, or locked up at home?The answer is obvious, we have no choice!

At present, nearly one million people have been vaccinated with four vaccines in China. However, the side effects of Pfizer vaccine, such as severe allergy, and whether some immunocompromised people, such as children, cancer patients, organ transplants, pregnant women and AIDS, can be vaccinated, and who can be vaccinated, have also become consistent issues and choices faced by China and the United States. However, the problems encountered in the vaccination of Pfizer vaccine and Modana vaccine in the United States and the United Kingdom will also serve as a reference for the China vaccine that will be widely vaccinated in the future.

First, who will be vaccinated first? What is the final goal?

According to the discussion results of CDC on November 30th, the order of COVID-19 vaccination is as follows:

First batch(From 15 December): frontline medical staff(20 million)And the elderly in nursing homes(millions).

So far, Pfizer will provide 40 million doses of vaccine before the end of the year; Moderna will provide 20 million doses before the end of the year.

Second batch(From January next year)Social necessities, including police, postmen, firefighters, dieters, school teachers, cleaners, food processors, etc.(nearly 90 million). Old people over 65 years old(fifty million).

The third batch: ordinary people(From March next year)It is estimated that more than 100 million people.

The fourth batch: young people and children under the age of 16(From May next year): tens of millions.

MD Anderson medical staff were among the first to be vaccinated. The hospital has subdivided the first batch of personnel:

At present, the Texas government has announced the distribution number of the first batch of Pfizer vaccines in major hospitals. MD Anderson Hospital will receive nearly 5,000 doses of COVID-19 vaccine on the 14th.(two doses for one person), should be able to supply all the clinical medical staff of 1a with vaccination.(The hospital has nearly 1,000 full-time doctors, more than 20,000 full-time employees, and nearly 30,000 people for further study.).

Goal:Strive to reach 70% vaccination rate after June next year, and promote group immunization.(95% effective rate x70% vaccination rate =66.5% immunization rate). In other words, we should stick to wearing masks and social isolation until the end of June next year.(Biden asked people to hold on at least until the end of April). Clear goals, but a long way to go! What should developing countries do if developed countries plan like this?

Figure/COVID-19 vaccine samples developed by Pfizer and BioNTech.

Second, should cancer and other patients with immunodeficiency, or people with severe allergies be vaccinated?

Should cancer and other patients with immunodeficiency, or people with severe allergies be vaccinated? At present, in the third phase of clinical research, tumor patients receiving chemotherapy and radiotherapy, or patients with bone marrow and organ transplantation, HIV, etc., are not allowed to participate in the study because of potential immunosuppression. Therefore, the effect of these patients after vaccination is still a research problem. Related research is being prepared.Generally speaking, if radiotherapy and chemotherapy have stopped for more than one year, cancer patients can consider vaccination.

In addition, two cases of obvious allergic reactions occurred in the population vaccinated in the first week in Britain. Therefore,Experts warn patients with a history of severe allergies to be carefully vaccinated.

3. Should children and pregnant women be vaccinated?

In the current clinical study, neither pregnant women nor children under 12 years old were enrolled. Therefore,Vaccination for pregnant women is not recommended at present. As for teenagers and children(under 16 years old)No further data on safety and effectiveness will be available until May next year.

Fourth, should people who have been infected with COVID-19 be vaccinated?

For people who have been infected,Because the recently reported cases of secondary infection and natural immunity may only last for 3 to 6 months, and the immunity produced by natural infection is weak, they should be vaccinated.

5. How long can immunity last after vaccination?

Since most of the third phase of vaccine research began in July this year, the longest observation time is less than half a year. Therefore, we can only conclude that the validity period is more than half a year at present. As for how long, we have to wait for the data to speak. According to the current state(Including the titer and maintenance of antibodies in early studies)It may be a year or so, I hope it will be longer.

6. After vaccination, will it spread the virus to others? Do you still need to wash your hands, wear a mask and be socially isolated?

At present, the effective rate of mRNA vaccine is 95%, which means that the difference between the number of patients with symptoms accounts for the percentage of the number of patients with symptoms in the control group compared with the random control group that did not receive the vaccine. This is a standard algorithm widely accepted by epidemiology, and it is also a standard index of vaccine listing in the international community, not an invention of a manufacturer. Both Pfizer and Mardner’s vaccine trials rely on patients’ self-reports, and subsequent confirmation tests will only be conducted if there are related symptoms. Therefore, this calculation does not include asymptomatic patients; Secondly, the difference between the two groups in transmission to others has not been detected yet.

Can the vaccine reduce the chance of transmission to others? Scientifically, it should be, but the degree needs further study. Therefore,After the vaccination, it is not necessary to wash your hands, wear masks and be socially isolated. Let’s stick to it for a while and wait for further data.Moreover, the vaccine is not 100% effective, in case you belong to the 5% ineffective population!

Figure/Relevant data of Pfizer vaccine

7. How many times should I be vaccinated? What are the side effects?

Current vaccines all requireInoculate twice. If you only plant it once, the effect will be greatly reduced. Moreover, there must be an interval of three weeks between two times.(Pfizer)Or around.(Mardner). At the same time, the vaccine from the same manufacturer must be vaccinated, even though they are all mRNA vaccines.

As for the side effects, it is a three-point poison. It is an ideal to cure all diseases without side effects; More accurately, it is a fantasy; Be strict, it’s nonsense!

This year, according to the recommendation of CDC in the United States, I have been vaccinated against influenza.(once a year, inactivated vaccine)And herpes zoster vaccine.(Protein vaccine, over 50 years old, administered twice). COVID-19 vaccine is expected to be vaccinated in late December. I don’t have much discomfort after getting the flu vaccine. However, every time I have been vaccinated with herpes zoster vaccine, I have intermittent fever for more than 24 hours, and sometimes fever also causes my whole body to tremble, and my arm is red, swollen and painful for nearly a week. However, I know that these are normal phenomena and belong to mild and moderate side effects.

Based on the available data, most of the side effects of COVID-19 vaccine last for 1-2 days. Common injection site pain, erythema/redness, or fatigue.（Moderna）9.7%, Pfizer（Pfizer）3.8%, fever, chills, muscle aches（ Moderna）8.9%, joint pain（Moderna） 5.2%, headache　（Moderna）4.5%, Pfizer（Pfizer） 2%。

Long-term side effects need to be followed up in the fourth phase after marketing.

Judging from the information released,MRNA vaccine appears severe(three degrees)The side effect was severe fatigue, accounting for 3.7%. Overall, it is very safe.Mild and moderate discomfort similar to a cold is very common and normal. Please be patient!

Figure/After the first vaccination, patients will get a card to remind them to get the second vaccination on time.

8. Will the new virus mutation affect the effectiveness of the vaccine?

The answer is possible. For example, the mutation rate of influenza virus gene is high, so a new vaccine against influenza in that year should be vaccinated every year. And AIDS has always been because the virus mutates too fast, so far there is no vaccine.

Fortunately, according to the current epidemiological survey, Nature Communications magazine published an article in November this year to study 46,000 cases of COVID-19 virus from different periods around the world, and found that the probability of COVID-19 mutation is relatively low because of its unique proofread inspection mechanism, which is undoubtedly the gospel of the vaccine. At the same time, the mRNA vaccine can be modified according to mutation and then reproduced, which is much easier to operate than the terminal protein vaccine. For example, the gun has been built, just need to modify the structure of the warhead.

9. Why should vaccine storage be at MINUS 70 degrees?

Pfizer vaccine needs to be stored in a freezer at MINUS 70 degrees Celsius for a long time, and it can only be stored in a refrigerator at 2 ~ 7 degrees Celsius for 5 days. Moderna vaccine can be stored for a long time in the freezer at MINUS 20 degrees, and can be stored in the refrigerator at 2 ~ 7 degrees for one month. The reason why RNA is sensitive to temperature is that it is easy to degrade with the increase of temperature. Moderna vaccine is relatively thermotolerant, which may be related to the composition and structure of its lipid carrier. This partly explains that the side effects of Moderna vaccine seem to be a little high.

AstraZeneca’s vaccine is an adenovirus strain, which requires lower temperature and can be stored for half a year at 2 ~ 7 degrees. And is suitable for developing countries.(Note: Freund’s temperature F is used in American charts). However, the comprehensive effective rate of AZ vaccine is about 70%. Subgroup analysis showed that the effective rate of the first low dose group was 90%. However, because this group of people is young.(under 50 years old)And it is not designed in advance. Therefore, it is recognized by the industry as 70% efficient.

Photo/Pfizer is building a "frozen farm" the size of a football field to store vaccines in Kalamazoo, Michigan. Pfizer’s vaccine must be stored below the ultra-low temperature of 70 degrees.

X. Why do Britain and America prefer mRNA vaccine?

On December 2nd, Britain took the lead in approving Pfizer’s vaccine and started vaccination on the 8th. Today, the vaccine has also been approved in the United States, and it is expected to start nationwide vaccination on the 15th. On the 17th of next week, the FDA of the United States is very likely to approve the mRNA vaccine of Moderna, and it is possible to start vaccination on the 22nd. Apart from the fact that these two viruses first completed the phase III clinical randomized study, what factors made the world look at the mRNA vaccine with new eyes?

Thirty years ago, I transferred from tumor immunology research to a brand-new field of tumor gene therapy. At the MD Anderson Cancer Center in the United States, my colleagues and I spent seven years constructing a retrovirus, adenovirus and nanoliposome-mediated anti-cancer gene transformation mode and animal tumor model, which not only contributed to the first patient’s cancer gene therapy in human history, but also made a Nasdaq-listed company. I have published more than a dozen papers myself, won two patents for gene therapy, and obtained a doctorate in tumor biology within four years. After that, I decided to return to the clinical front line and started five years of standardized training for clinical oncology residents.

Retroviruses have the longest gene transformation rate and maintenance time, but unfortunately they will be integrated into the DNA of human hosts. Some scholars are worried about the possibility of cancer. At present, this gene transformation method has been rarely used in cancer treatment.

Adenovirus will not be integrated into human DNA, but it is toxic to cells and will cause immunity to adenovirus vectors. This may explain the side effects of AstraZeneca COVID-19 adenovirus vector vaccine and the change of the initial dose to the effective rate.The high dose of the first vaccination may stimulate a stronger immune response against adenovirus vector, which may affect the results of the second vaccination. Therefore, it is better to use a low dose for the first time).

However, nanotechnology liposome itself has little influence on the immune system, and the general mRNA will not be reverse transcribed and integrated into human DNA, but it will express the protein to be transmitted in human cells for a short time.(For example, COVID-19 spinous protein activates the immune response and then gradually subsides), the best security. However, I used DNA plasmid at that time; Because DNA is much more stable. At that time, everyone knew that RNA extraction and preservation were very difficult, and there was no precedent for successful transformation of mRNA gene.

Gene transfer with COVID-19 spinous protein mRNA as the main body mediated by lipid carrier can avoid errors and potential side effects in the process of DNA transcription, so that spinous protein can be efficiently expressed in human cells in a short time, and the immune response of the body can be activated, which can produce specific antiviral antibodies and immune killer cells more effectively than natural infection. Although the gene expression is short-lived, activated B cells and T cells have their own memories, which can destroy or inhibit the virus for a long time. At the same time, this mRNA will not reverse transcribe into DNA, and will not be integrated into the host DNA, which is safe and reliable.

For decades, the method of mRNA gene transfer has been a dream of scientists. Katalin Kariko, the founding partner of Moderna, the inventor of mRNA technology and a Hungarian-born American scientist, has been on the bench for 40 years, and was originally prepared to set up Moderna to engage in mRNA cancer vaccine. As a result, a Cheng Yaojin COVID-19 was killed halfway.

When scientists in China announced the gene sequence of COVID-19 on January 10th this year.(including spinous process protein)Later, the researchers in the United States and Germany changed hands, but they were unwilling to plant flowers and flowers. Fortunately, this spinous protein was finally proved to be a good immunogen of COVID-19, and COVID-19 mRNA vaccine appeared on the scene. This is an important breakthrough in human science and technology, and it is also the result of the joint efforts of scientists from all over the world.

In contrast, inactivating virus vaccine is a mature method, and this traditional method is adopted in the annual influenza vaccine. Its research and development success rate is high, so it is widely used. However, it is difficult to control the temperature during inactivation, which brings some difficulties to quality control. Therefore, the production capacity is limited. At the same time, the added chemicals will also bring some side effects.

Generally, the effective rate of inactivated influenza vaccine is between 50% and 70%. At present, the early toxicity and antibody positive rate of domestic COVID-19 vaccine with inactivated vaccine as the main body and adenovirus vector have been reported. Volunteers can tolerate mild and moderate side effects, and the antibodies are positive after injection. However, positive antibody does not guarantee that it has sufficient protection. The effective rate must be obtained in the three-phase randomized study with control group. Because the epidemic situation in China is well controlled, the corresponding research must be carried out in other countries with high incidence.

Up to now, the epidemiological efficiency of the strict phase III clinical randomized study of vaccines in China has not been reported, and the world is eagerly awaiting it. I believe the final conclusion will be heard in the near future.The advantages of inactivated vaccine and adenovirus vector vaccine are that they are less affected by temperature, easy to store and transport, and more suitable for developing countries.

Due to the potential advantages of technological innovation and high antigen purification and expression, such as improving vaccine efficiency and productivity and reducing side effects, when the effective rate of mRNA COVID-19 vaccine reached 95%, the industry unanimously hailed this major breakthrough. More importantly, there are almost no seriously ill patients among the vaccinators.

Many people think that this is the arrival of God’s grace! Developed countries such as the United States and Britain have booked the products of these two companies in advance. China’s Fosun Company also signed a cooperation agreement with Pfizer and has completed the first phase of clinical trials. It is expected that the related Phase 2 will be launched in China soon.(Non-random)Clinical research to obtain the approval of China FDA.

Figure/A nurse and patient in California. In many parts of the United States, the pressure on the health system has been overwhelmed and is on the verge of collapse at any time.

Although American health insurance and the government will pay the cost of vaccination, another difficulty is that more than 37% people in the United States are not at ease with the vaccine and are not prepared to vaccinate immediately. In this regard, three former presidents of the United States, Bush, Clinton and Obama, said that they would vaccinate under the observation of the media at the first time as a platform for vaccine safety.

Because the vaccine is for normal people, it is not a "medicine", not to treat patients, but to prevent diseases. Meanwhile, for COVID-19 vaccine, the population to be vaccinated is billions of healthy people, including children.Therefore, its safety must be much stricter than that of "medicine".Therefore, if time is not pressing, all new vaccines should wait for a long time.(more than 2 years)The data will be finally approved. But in the face of a serious epidemic, this is irrational. The regulations that allow emergency use are designed for this situation.

At present, FDA requires that the last patient should be observed for at least 2 months after entering the Phase III clinical study to ensure that there are no serious acute side effects. Moreover, regulators must strictly control the use of these new vaccines from the beginning. The initial use of these vaccines is limited to those who need them most-doctors, nurses, other health care workers, and the elderly in nursing homes. Regulators also need to continue to closely monitor the side effects of vaccines already on the market.(so-called Phase IV Clinical Study). With the accumulation of data in the first two months of next year, the range of vaccinators will be further expanded.

The development of human society always strives for survival first, and then for improvement and perfection.

When the hopes of the whole world are pinned on the COVID-19 vaccine, the hardest work has just begun. We know that the best antiviral function of the vaccine will not be realized until two weeks after the second vaccination.In other words, for most people, December this year, January and February next year will be the darkest moments in the medical history of the United States since the Spanish influenza pandemic in World War I.

According to Dr. Fauci, director of the Institute of Infectious Diseases of the National Institutes of Health, it is estimated that by March next year, about 500,000 people in the United States will die in COVID-19, surpassing the number of deaths in World War II in the United States.(about 400,000). Regrettably, some people in the United States still refuse to wear masks and social isolation. Up to now, 37% people are skeptical about vaccines, and the epidemic prevention work has a long way to go!

Controversy over vaccines(Inoculation or non-inoculation, domestic or imported)The reason and background are very complicated, and it will not stop for a while. As a scientist and a doctor, I care most about yourself! Vaccinate, not only for others, but also for yourself!

This article comes from WeChat WeChat official account:CC weekly (id: cancer-weekly), Author: Zhang Yujiao (tenured professor of The University of Texas MD Anderson Cancer Center)

　　The reference news network reported on October 30.On October 24th, the website of Tanzania’s Daily News published an article entitled "How the Belt and Road Initiative is Changing the African Economy" by George Montu. The article is compiled as follows:

　　This year marks the 10th anniversary of the Belt and Road Initiative.

　　Through infrastructure investment and regional cooperation, the Belt and Road Initiative has enhanced the connectivity between China and the rest of the world.

　　It should be pointed out that although the Belt and Road Initiative was put forward by China, it belongs to the whole world and benefits all mankind. Empirical evidence shows that the Belt and Road Initiative has accelerated the economic development of African countries and promoted regional integration in Africa.

　　In the 10 years since the "Belt and Road Initiative" was put forward, the cumulative trade volume between China and Africa has exceeded 2 trillion US dollars. As direct flights have been opened between Nairobi and Changsha, a city in central China, Kenyan flowers can be sold to China businessmen in Changsha and its surrounding areas.

　　According to the Ministry of Foreign Affairs of China, China’s investment in Africa has grown steadily. In the first half of this year, China’s new direct investment in Africa reached US$ 1.82 billion, a year-on-year increase of 4.4%. At present, there are more than 3,000 China enterprises "deeply ploughing into Africa", and private enterprises account for more than 70% of China’s non-enterprises and they are the pillars of China’s investment in Africa.

　　Statistics from Tanzania Investment Center show that from 1997 to August 2023, thousands of China projects were registered in Tanzania, creating about 150,000 jobs.

　　The Belt and Road Initiative has contributed to poverty reduction in Africa. According to the World Bank’s forecast, by 2030, the "Belt and Road" international cooperation will lift 7.6 million people out of extreme poverty and 32 million people out of moderate poverty.

　　Since the beginning of this century, China has built more than 6,000 kilometers of railways, 6,000 kilometers of highways, nearly 20 ports and more than 80 large-scale power facilities in Africa.

　　In Tanzania, we see that China contractors are undertaking many flagship infrastructure projects, including the fifth and sixth sections of Tanzania Central Line Standard Gauge Railway, dodoma Msarato International Airport, Kigongo-Busisi Bridge and so on.

　　These strategic infrastructure projects will greatly facilitate the flow of goods and people in related fields, reduce energy consumption and telecommunications costs, and improve Tanzania’s investment environment. Despite the aforementioned benefits, some westerners claim that China is using the Belt and Road Initiative to exploit Africa. They fabricated concepts such as "debt trap diplomacy" and "opaque pricing" to tarnish the image of the "Belt and Road Initiative".

　　These accusations are groundless. Look at Africa’s infrastructure. The Belt and Road Initiative is helping Africa achieve transformation, and no African country has fallen into the so-called "debt trap". Over the years, African countries have failed to make progress due to backward infrastructure and the lack of willingness of traditional partners to help finance important infrastructure construction.

　　However, since China became an economic power, it has been actively involved in providing assistance to the strategic infrastructure construction for promoting economic growth in African countries.

　　Because of the effectiveness of the Belt and Road Initiative, Africa’s traditional development partners who have been exploiting for a long time find it difficult to compete with this initiative proposed by China, because it is based on long-term friendship and win-win cooperation.

　　Obviously, the Belt and Road Initiative provides a platform for African low-and middle-income economies to achieve remarkable growth in infrastructure construction, job creation and trade opportunities.

　　As Tanzanian President Samia Suluhu Hassan said during his meeting with the Supreme Leader of China president in Johannesburg in August this year, Tanzania and other developing countries have benefited a lot from the joint construction of the Belt and Road Initiative.

　　We Africans know what we need and who our true friends are. The denigration of the Belt and Road Initiative by some Westerners will not affect our judgment on this grand strategy put forward by China but shared by all mankind. (Compile/sha li)